Recombinant COVID-19 NSP1 protein, His-tagged

• Cat.No.: NSP1-001V
• Product Overview: Recombinant COVID-19 NSP1 full length or partial length protein was fused to His-tag and expressed in HEK293.

Specification

• Species: Sars-CoV-2
• Source: HEK293
• Tag: His
• Description: Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.
• Form: PBS, pH7.4.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >80%
• Storage: Store it at 4 ºC for short time. For long term storage, store it at -20ºC to -80ºC.
• Warning: For Research Use Only.

Gene Information

• Gene Name: orf1ab
• Official Symbol: orf1ab
• Synonyms: pp1ab
• Gene ID: 1489680
• Protein Refseq: NP_828860.2
• UniProt ID: P0C6X7