Recombinant Cynomolgus FXN Protein, His-tagged

• Cat.No.: FXN-530C
• Product Overview: Recombinant Cynomolgus FXN full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Cynomolgus
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: FXN frataxin [ Macaca fascicularis (crab-eating macaque) ]
• Official Symbol: FXN
• Synonyms: FXN; frda1
• Gene ID: 102120656
• mRNA Refseq: NM_001285038
• Protein Refseq: NP_001271967
• UniProt ID: Q8HXX9

Reviews

01/28/2021

Customer service was courteous and efficient, guiding us through the product selection process with expertise.

12/20/2019

The consistent quality of this product has made it a staple in our lab, contributing to the success of various research projects.

09/02/2018

Delivery was quick and hassle-free, allowing us to proceed with our experiments without any unnecessary delays.

Q&As

Can you elaborate on the interactions between FXN and iron regulatory proteins in the cell?

FXN interacts with iron regulatory proteins, influencing cellular iron homeostasis by modulating the expression of genes involved in iron metabolism.

What is the impact of FXN deficiency on the sensitivity of cells to oxidative stress?

FXN deficiency increases cellular sensitivity to oxidative stress due to the disruption of iron homeostasis, leading to the accumulation of reactive oxygen species and cellular damage.

Can you explain the chemistry behind the iron-sulfur cluster assembly facilitated by FXN?

FXN assists in the formation of iron-sulfur clusters by providing a scaffold for the assembly of iron and sulfur atoms, promoting the stability and functionality of these clusters.

How does FXN contribute to the regulation of cellular energy metabolism?

FXN influences cellular energy metabolism by supporting the function of iron-sulfur cluster-containing enzymes involved in key metabolic pathways, such as the tricarboxylic acid (TCA) cycle.

How does FXN deficiency lead to Friedreich's ataxia on a molecular level?

FXN deficiency results in impaired iron-sulfur cluster assembly, leading to mitochondrial dysfunction, oxidative stress, and ultimately causing Friedreich's ataxia.