Recombinant Cynomolgus monkey CSF1R Protein, His-tagged
Cat.No. : | CSF1R-371C |
Product Overview : | Recombinant Cynomolgus monkey CSF1R protein with His tag was expressed in HEK293. |
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Description : | The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. |
Source : | HEK293 |
Species : | Cynomolgus monkey |
Tag : | His |
Form : | Lyophilized |
Molecular Mass : | 57.1 kDa |
Protein length : | 1055 |
AA Sequence : | MRLCSSFAFRYDSEASSAMLNWEEE DQPKEEEEENKTNSQCRGEERVSGV PIPAELVPGSSVPWAPYSPAPACRF PTEAMGPGVLLLLLVVTAWHGQGIP VIEPSGPELVVKPGETVTLRCVGNG SVEWDGPISPHWTLYSDGPSSVLTT NNATFQNTRTYRCTEPGDPLRGSAA IHLYVKDPARPWNVLAKEVVVFEDQ DALLPCLLTDPVLEAGVSLVRLRGR PLLRHTNYSFSPWHGFIIHRAKFIQ GQDYQCSALMGGRKVMSISIRLKVQ KVIPGPPALTLVPEELVRIRGEAAQ IVCSASNIDVDFDVFLQHNTTKLAI PQRSDFHDNRYQKVLTLSLGQVDFQ HAGNYSCVASNVQGKHSTSMFFRVV ESAYLDLSSEQNLIQEVTVGEGLNL KVMVEAYPGLQGFNWTYLGPFSDHQ PEPKLANATTKDTYRHTFTLSLPRL KPSEAGRYSFLARNPGGWRALTFEL TLRYPPEVSVIWTSINGSGTLLCAA SGYPQPNVTWLQCAGHTDRCDEAQV LQVWVDPHPEVLSQEPFQKVTVQSL LTTETLEHNQTYECRAHNSVGSGSW AFIPISAGARTHPPDEFLFTPVVVA CMSVMALLLLLLLLLLYKYKQKPKY QVRWKIIESYEGNSYTFIDPTQLPY NEKWEFPRNNLQFGKTLGAGAFGKV VEATAFGLGKEDAVLKVAVKMLKST AHADEKEALMSELKIMSHLGQHENI VNLLGACTHGGPVLVITEYCCYGDL LNFLRRKAEAMLGPSLSPGQDPEGG ADYKNIHLEKKYVRRDSGFSSQGVD TYVEMRPVSTSSNDSFSEQDLDKED GRPLELWDLLHFSSQVAQGMAFLAS KNCIHRDVAARNVLLTNGHVAKIGD FGLARDIMNDSNYIVKGNARLPVKW MAPESIFDCVYTVQSDVWSYGILLW EIFSLGLNPYPGILVNSKFYKLVKD GYQMAQPAFAPKNIYSIMQACWALE PTHRPTFQQICSLLQEQAQEDRRER DYTNLPSSSRSGGSGSGSSSSSSEP EEESSSEHLACCEQGDIAQPLLQPN NYQFC |
Purity : | > 98% |
Applications : | WB; ELISA; FACS; FC |
Stability : | This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : | At -20 centigrade. |
Concentration : | 1 mg/mL |
Storage Buffer : | PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
Reconstitution : | Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
Gene Name : | CSF1R colony stimulating factor 1 receptor [ Macaca mulatta (Rhesus monkey) ] |
Official Symbol : | CSF1R |
Synonyms : | CSF1R; colony stimulating factor 1 receptor; macrophage colony-stimulating factor 1 receptor; |
Gene ID : | 711512 |
mRNA Refseq : | XM_001107711 |
Protein Refseq : | XP_001107711 |
UniProt ID : | F7BTH9 |
Products Types
◆ Recombinant Protein | ||
CSF1R-6754C | Recombinant Cynomolgus CSF1R protein, His-tagged | +Inquiry |
Csf1r-337M | Recombinant Mouse CSF1R protein(Met1-Ser511), His-tagged | +Inquiry |
CSF1R-373H | Recombinant Human CSF1R Protein, His-tagged | +Inquiry |
CSF1R-1319H | Recombinant Human CSF1R Protein (Y538-C972), Tag Free | +Inquiry |
Csf1r-4000M | Recombinant Mouse Csf1r protein, His-tagged | +Inquiry |
◆ Lysates | ||
CSF1R-444HCL | Recombinant Human CSF1R cell lysate | +Inquiry |
CSF1R-2091MCL | Recombinant Mouse CSF1R cell lysate | +Inquiry |
CSF1R-823RCL | Recombinant Rat CSF1R cell lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewWith its remarkable quality, reliability, and the manufacturer's excellent technical support, I am confident that it will be an invaluable asset in driving my scientific inquiries forward and facilitating groundbreaking discoveries in my field.
This variety allows me to select the most appropriate option based on the specific requirements of my research.
the manufacturer's commitment to quality control and rigorous testing guarantees the reliability and reproducibility of the CSF1R protein, which is essential for obtaining accurate and consistent results.
Q&As (5)
Ask a questionYes, drugs like pexidartinib have been approved for the treatment of certain rare tumors called tenosynovial giant cell tumors (TGCT) that overexpress CSF1R.
CSF1R inhibitors can modulate the tumor microenvironment by reducing the number of tumor-associated macrophages and promoting an anti-tumor immune response.
Yes, CSF1R inhibitors are often used in combination with chemotherapy and immunotherapy to enhance treatment effectiveness.
CSF1R inhibitors are being investigated for cancer therapy to block tumor-promoting macrophages and slow down cancer progression.
Research is ongoing, and CSF1R inhibitors are being explored as a potential therapy for neurodegenerative diseases, but no FDA-approved treatments currently exist.
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