Recombinant Cynomolgus Monkey IL3RA Protein, hIgG1-tagged

• Cat.No.: IL3RA-1578C
• Product Overview: Recombinant Cynomolgus Monkey IL3RA Protein with hIgG1 tag was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.
• Source: HEK293
• Species: Cynomolgus Monkey
• Tag: Fc
• Form: Lyophilized
• Endotoxin: < 1 EU/μg (determined by the LAL method)
• Purity: > 85 % by SDS-PAGE
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Lyophilized from 0.2 μm filtered solution in PBS buffer with 5 % trehalose and 5 % mannitol.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/mL.

Gene Information

• Gene Name: IL3RA interleukin 3 receptor subunit alpha [ Macaca mulatta (Rhesus monkey) ]
• Official Symbol: IL3RA
• Synonyms: IL3RA; interleukin 3 receptor subunit alpha; interleukin-3 receptor subunit alpha
• Gene ID: 106995138
• mRNA Refseq: XM_028842961
• Protein Refseq: XP_028698794
• UniProt ID: G8F1N5

Reviews

07/24/2022

In special environment, good stability.

05/25/2022

Good crystallization property and good effect.

06/29/2021

Has the expected biological activity, such as enzyme activity and receptor binding activity, and so on.

Q&As

Can Il3ra be personalized?

The feasibility of personalized therapy depends on the specific disease type and patient situation, and more research is needed to determine the application of personalized therapy to Il3ra.

Does Il3ra have clinical application prospects? What are the prospects?

Il3ra has certain promise in clinical application, especially in the treatment of immune-related diseases.

What is the action mechanism of Il3ra?

Regulates the proliferation and differentiation of immune cells by binding to its interacting cytokine IL-3, and plays a role in regulating the function of the immune system.

How is the clinical trial of Il3ra progressing?

Clinical trials of recombinant Il3ra have been conducted in different disease areas. At present, some early trials show its potential in the treatment of certain diseases, but more research is needed to verify its efficacy and safety.

What is the specific effect of Il3ra on the immune system?

The Il3ra can regulate the proliferation and differentiation of different types of immune cells in the immune system, thus affecting the function of the immune system.

Does Il3ra have side effects?

Il3ra is generally well tolerated, but some minor side effects such as headache and nausea may occur. Serious side effects are rare.