Recombinant Cynomolgus MSLN Protein, C-His tagged

Cat.No. : MSLN-26C
Product Overview : Recombinant Cynomolgus MSLN Protein with C-His tag was expressed in Human cells.
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Description : This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Source : Human cells
Species : Cynomolgus
Tag : C-His
AA Sequence : DVERTTCPPEKEVHEIDESLIFYKK RELEACVDAALLAAQMDRVDAIPFT YEQLDVLKHKLDELYPQGYPESVIR HLGHLFLKMSPEDIRKWNVTSLETL KALLKVSKGHEMSAQVATLIDRVVV GRGQLDKDTADTLTAFCPGCLCSLS PERLSSVPPSIIGAVRPQDLDTCGP RQLDVLYPKARLAFQNMSGSEYFVK IRPFLGGAPTEDLKALSQQNVSMDL ATFMKLRREAVLPLSVAEVQKLLGP HVEGLKVEEQHSPVRDWILKQRQDD LDTLGLGLQGGIPNGYLILDLSVRE ALSGTPCLLGPGPHHHHHHHHHH
Endotoxin : < 1.0 EU/μg of the protein by the LAL method.
Purity : > 90% by SDS-PAGE
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Concentration : 1.0 mg/mL
Storage Buffer : Supplied as a 0.2 μm filtered solution in PBS (pH 7.4)
SDS-PAGE: Line1: 3 μg/Line, Reduced<br />Line2: 3 μg/Line, Non-reduced
Gene Name : MSLN mesothelin [ Macaca fascicularis (crab-eating macaque) ]
Official Symbol : MSLN
Synonyms : MSLN; mesothelin
Gene ID : 102130460
mRNA Refseq : XM_045382794
Protein Refseq : XP_045238729

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary role of MSLN in normal tissues? 12/07/2022

MSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.

How is MSLN expression altered in cancerous cells? 03/19/2022

In cancer, MSLN expression is significantly upregulated.

In which types of cancer is MSLN overexpressed? 03/28/2021

MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.

Are there any therapeutic strategies targeting MSLN in cancer treatment? 02/25/2020

Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.

How can MSLN levels be detected and measured in clinical settings? 10/07/2019

MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.

What is the prognostic significance of MSLN overexpression in cancer patients? 11/23/2018

MSLN overexpression is often associated with poor prognosis in cancer patients.

How does MSLN contribute to cancer progression and metastasis? 11/07/2018

MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.

Customer Reviews (3)

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Reviews
05/22/2022

    Very satisfied, great product.

    03/06/2022

      Product is high-quality.

      09/30/2021

        Excellent for experiments, reliable.

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