Recombinant Cynomolgus MSLN Protein, Fc tagged
Cat.No. : | MSLN-25C |
Product Overview : | Recombinant Cynomolgus MSLN Protein with Fc-tag was expressed in Human cells. |
Availability | July 26, 2024 |
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Description : | This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
Source : | Human cells |
Species : | Cynomolgus |
Tag : | Fc |
AA Sequence : | DVERTTCPPEKEVHEIDESLIFYKK RELEACVDAALLAAQMDRVDAIPFT YEQLDVLKHKLDELYPQGYPESVIR HLGHLFLKMSPEDIRKWNVTSLETL KALLKVSKGHEMSAQVATLIDRVVV GRGQLDKDTADTLTAFCPGCLCSLS PERLSSVPPSIIGAVRPQDLDTCGP RQLDVLYPKARLAFQNMSGSEYFVK IRPFLGGAPTEDLKALSQQNVSMDL ATFMKLRREAVLPLSVAEVQKLLGP HVEGLKVEEQHSPVRDWILKQRQDD LDTLGLGLQGGIPNGYLILDLSVRE ALSGTPCLLGPGP |
Endotoxin : | < 1.0 EU/μg of the protein by the LAL method. |
Purity : | > 90% by SDS-PAGE |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Concentration : | 1.0 mg/mL as determined by BCA method |
Storage Buffer : | Supplied as a 0.2 μm filtered solution in PBS (pH 7.4) |
Gene Name : | MSLN mesothelin [ Macaca fascicularis (crab-eating macaque) ] |
Official Symbol : | MSLN |
Synonyms : | MSLN; mesothelin |
Gene ID : | 102130460 |
mRNA Refseq : | XM_045382794 |
Protein Refseq : | XP_045238729 |
Products Types
◆ Lysates | ||
MSLN-1343HCL | Recombinant Human MSLN cell lysate | +Inquiry |
MSLN-1316HCL | Recombinant Human MSLN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewVery satisfied, great product.
Product is high-quality.
Excellent for experiments, reliable.
Q&As (7)
Ask a questionMSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.
In cancer, MSLN expression is significantly upregulated.
MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.
Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.
MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.
MSLN overexpression is often associated with poor prognosis in cancer patients.
MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.
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