Recombinant E. coli rnhA protein, His-tagged
Cat.No. : | rnhA-152 |
Product Overview : | Recombinant E. coli rnhA fused with His tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | RNHA is an endonuclease which specifically degrades the RNA of RNA-DNA hybrids. Localized to the nucleus, the RNHA protein mediates the removal of Okazaki fragment RNA primers which are present on the lagging strand during DNA replication. RNHA catalyzes the endonucleolytic cleavage of RNA to a 5'-phosphomonoester and is capable of binding magnesium or manganese as cofactors. |
Source : | E. coli |
Species : | E. coli |
Tag : | His |
Form : | RNASEH1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 2mM DTT. |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSMLKQVEI FTDGSCLGNP GPGGYGAILR YRGREKTFSA GYTRTTNNRM ELMAAIVALE ALKEHCEVIL STDSQYVRQG ITQWIHNWKK RGWKTADKKP VKNVDLWQRL DAALGQHQIK WEWVKGHAGH PENERCDELA RAAAMNPTLE DTGYQVEV. |
Purity : | Greater than 95% as determined by SDS-PAGE. |
Storage : | Store at 4 centigrade if entire vial will be used within 2-4 weeks. Store, frozen at -20 centigrade for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
Gene Name : | rnhA ribonuclease HI, degrades RNA of DNA-RNA hybrids [ Escherichia coli str. K-12 substr. MG1655 ] |
Official Symbol : | rnhA |
Synonyms : | cer; dasF; ECK0214; herA; JW0204; rnh; sdrA; sin |
Gene ID : | 946955 |
Products Types
◆ Recombinant Protein | ||
RnhA-739E | Recombinant E.coli rnhA | +Inquiry |
rnhA-1012E | Recombinant E.coli RnhA, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionWhile the primary focus is on therapeutic applications, the RNHA protein's detection and quantification may have diagnostic potential in identifying antibiotic-resistant bacterial strains.
Current research efforts are focused on understanding the structure and function of the RNHA protein, identifying potential inhibitors, and evaluating their efficacy in combating antibiotic-resistant infections.
Yes, targeting the RNHA protein may lead to the development of novel antibiotic adjuvants or even entirely new classes of antibiotics that can overcome bacterial resistance mechanisms.
The RNHA protein reduces the intracellular concentration of antibiotics, leading to decreased efficacy and contributing to antibiotic resistance.
One challenge is developing inhibitors that specifically target the RNHA protein without affecting essential cellular functions in both bacteria and humans.
Customer Reviews (3)
Write a reviewThe RNHA protein comes highly recommended for its outstanding performance in ELISA assays.
One notable advantage of the RNHA protein is the excellent technical support provided by its manufacturer.
Renowned for its reliability and consistency, this protein offers researchers the confidence to achieve accurate and reproducible results in their studies.
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