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Recombinant E. coli rnhA protein, His-tagged

Cat.No. : rnhA-152
Product Overview : Recombinant E. coli rnhA fused with His tag at N-terminal was expressed in E. coli.
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Description : RNHA is an endonuclease which specifically degrades the RNA of RNA-DNA hybrids. Localized to the nucleus, the RNHA protein mediates the removal of Okazaki fragment RNA primers which are present on the lagging strand during DNA replication. RNHA catalyzes the endonucleolytic cleavage of RNA to a 5'-phosphomonoester and is capable of binding magnesium or manganese as cofactors.
Source : E. coli
Species : E. coli
Tag : His
Form : RNASEH1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 2mM DTT.
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSMLKQVEI FTDGSCLGNP GPGGYGAILR YRGREKTFSA GYTRTTNNRM ELMAAIVALE ALKEHCEVIL STDSQYVRQG ITQWIHNWKK RGWKTADKKP VKNVDLWQRL DAALGQHQIK WEWVKGHAGH PENERCDELA RAAAMNPTLE DTGYQVEV.
Purity : Greater than 95% as determined by SDS-PAGE.
Storage : Store at 4 centigrade if entire vial will be used within 2-4 weeks.
Store, frozen at -20 centigrade for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Gene Name : rnhA ribonuclease HI, degrades RNA of DNA-RNA hybrids [ Escherichia coli str. K-12 substr. MG1655 ]
Official Symbol : rnhA
Synonyms : cer; dasF; ECK0214; herA; JW0204; rnh; sdrA; sin
Gene ID : 946955

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◆ Recombinant Protein
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any diagnostic applications of the RNHA protein? 07/26/2022

While the primary focus is on therapeutic applications, the RNHA protein's detection and quantification may have diagnostic potential in identifying antibiotic-resistant bacterial strains.

What are the current research efforts focused on regarding the RNHA protein's clinical applications? 05/21/2021

Current research efforts are focused on understanding the structure and function of the RNHA protein, identifying potential inhibitors, and evaluating their efficacy in combating antibiotic-resistant infections.

Can targeting the RNHA protein lead to the development of new classes of antibiotics? 05/07/2021

Yes, targeting the RNHA protein may lead to the development of novel antibiotic adjuvants or even entirely new classes of antibiotics that can overcome bacterial resistance mechanisms.

How does the RNHA protein impact the efficacy of existing antibiotics? 01/17/2018

The RNHA protein reduces the intracellular concentration of antibiotics, leading to decreased efficacy and contributing to antibiotic resistance.

What are the challenges in targeting the RNHA protein for clinical applications? 08/28/2017

One challenge is developing inhibitors that specifically target the RNHA protein without affecting essential cellular functions in both bacteria and humans.

Customer Reviews (3)

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Reviews
08/18/2021

    The RNHA protein comes highly recommended for its outstanding performance in ELISA assays.

    04/10/2016

      One notable advantage of the RNHA protein is the excellent technical support provided by its manufacturer.

      02/23/2016

        Renowned for its reliability and consistency, this protein offers researchers the confidence to achieve accurate and reproducible results in their studies.

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