Recombinant Full Length Human AIRE Protein, C-Flag-tagged
Cat.No. : | AIRE-1123HFL |
Product Overview : | Recombinant Full Length Human AIRE Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 57.5 kDa |
AA Sequence : | MATDAALRRLLRLHRTEIAVAVDSA FPLLHALADHDVVPEDKFQETLHLK EKEGCPQAFHALLSWLLTQD STAILDFWRVLFKDYNLERYGRLQP ILDSFPKDVDLSQPRKGRKPPAVPK ALVPPPRLPTKRKASEEARA AAPAALTPRGTASPGSQLKAKPPKK PESSAEQQRLPLGNGIQTMSASVQR AVAMSSGDVPGARGAVEGIL IQQVFESGGSKKCIQVGGEFYTPSK FEDSGSGKNKARSSSGPKPLVRAKG AQGAAPGGGEARLGQQGSVP APLALPSDPQLHQKNEDECAVCRDG GELICCDGCPRAFHLACLSPPLREI PSGTWRCSSCLQATVQEVQP RAEEPRPQEPPVETPLPPGLRSAGE EVRGPPGEPLAGMDTTLVYKHLPAP PSAAPLPGLDSSALHPLLCV GPEGQQNLAPGARCGVCGDGTDVLR CTHCAAAFHWRCHFPAGTSRPGTGL RCRSCSGDVTPAPVEGVLAP SPARLAPGPAKDDTASHEPALHRDD LESLLSEHTFDGILQWAIQSMARPA APFPSTRTRPLEQKLISEEDLAAND ILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome |
Protein Pathways : | Primary immunodeficiency, Ubiquitin mediated proteolysis |
Gene Name : | AIRE autoimmune regulator [ Homo sapiens (human) ] |
Official Symbol : | AIRE |
Synonyms : | APS1; APSI; PGA1; AIRE1; APECED |
Gene ID : | 326 |
mRNA Refseq : | NM_000383.4 |
Protein Refseq : | NP_000374.1 |
MIM : | 607358 |
UniProt ID : | O43918 |
Products Types
◆ Recombinant Protein | ||
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AIRE-6087Z | Recombinant Zebrafish AIRE | +Inquiry |
AIRE-3784H | Recombinant Human AIRE, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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