| Description : |
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
57.5 kDa |
| AA Sequence : |
MATDAALRRLLRLHRTEIAVAVDSA FPLLHALADHDVVPEDKFQETLHLK EKEGCPQAFHALLSWLLTQDSTAIL DFWRVLFKDYNLERYGRLQPILDSF PKDVDLSQPRKGRKPPAVPKALVPP PRLPTKRKASEEARAAAPAALTPRG TASPGSQLKAKPPKKPESSAEQQRL PLGNGIQTMSASVQRAVAMSSGDVP GARGAVEGILIQQVFESGGSKKCIQ VGGEFYTPSKFEDSGSGKNKARSSS GPKPLVRAKGAQGAAPGGGEARLGQ QGSVPAPLALPSDPQLHQKNEDECA VCRDGGELICCDGCPRAFHLACLSP PLREIPSGTWRCSSCLQATVQEVQP RAEEPRPQEPPVETPLPPGLRSAGE EVRGPPGEPLAGMDTTLVYKHLPAP PSAAPLPGLDSSALHPLLCVGPEGQ QNLAPGARCGVCGDGTDVLRCTHCA AAFHWRCHFPAGTSRPGTGLRCRSC SGDVTPAPVEGVLAPSPARLAPGPA KDDTASHEPALHRDDLESLLSEHTF DGILQWAIQSMARPAAPFPSTRTRP LEQKLISEEDLAANDILDYKDDDDK V |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
