| Description : |
The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Tag : |
GST |
| Molecular Mass : |
104.2 kDa |
| Protein Length : |
751 amino acids |
| AA Sequence : |
MEKATVPVAA ATAAEGEGSP PAVAAVAGPP AAAEVGGGVG GSSRARSASS PRGMVRVCDL LLKKKPPQQQ HHKAKRNRTC RPPSSSESSS DSDNSGGGGG GGGGGGGGGG TSSNNSEEEE DDDDEEEEVS EVESFILDQD DLENPMLETA SKLLLSGTAD GADLRTVDPE TQARLEALLE AAGIGKLSTA DGKAFADPEV LRRLTSSVSC ALDEAAAALT RMRAESTANA GQSDNRSLAE ACSEGDVNAV RKLLIEGRSV NEHTEEGESL LCLACSAGYY ELAQVLLAMH ANVEDRGIKG DITPLMAAAN GGHVKIVKLL LAHKADVNAQ SSTGNTALTY ACAGGYVDVV KVLLESGASI EDHNENGHTP LMEAGSAGHV EVARLLLENG AGINTHSNEF KESALTLACY KGHLEMVRFL LEAGADQEHK TDEMHTALME ACMDGHVEVA RLLLDSGAQV NMPADSFESP LTLAACGGHV ELAALLIERG ASLEEVNDEG YTPLMEAARE GHEEMVALLL GQGANINAQT EETQETALTL ACCGGFLEVA DFLIKAGADI ELGCSTPLME AAQEGHLELV KYLLAAGANV HATTATGDTA LTYACENGHT DVADVLLQAG ADLEHESEGG RTPLMKAARA GHVCTVQFLI SKGANVNRTT ANNDHTVLSL ACAGGHLAVV ELLLAHGADP THRLKDGSTM LIEAAKGGHT SVVCYLLDYP NNLLSAPPPD VTQLTPPSHD LTDNIFPRLV C |
| Applications : |
Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
