Recombinant Full Length Human ANXA11 Protein, C-Flag-tagged
Cat.No. : | ANXA11-1121HFL |
Product Overview : | Recombinant Full Length Human ANXA11 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
- Download
Description : | This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 54.2 kDa |
AA Sequence : | MSYPGYPPPPGGYPPAAPGGGPWGG AAYPPPPSMPPIGLDNVATYAGQFN QDYLSGMAANMSGTFGGANM PNLYPGAPGAGYPPVPPGGFGQPPS AQQPVPPYGMYPPPGGNPPSRMPSY PPYPGAPVPGQPMPPPGQQP PGAYPGQPPVTYPGQPPVPLPGQQQ PVPSYPGYPGSGTVTPAVPPTQFGS RGTITDAPGFDPLRDAEVLR KAMKGFGTDEQAIIDCLGSRSNKQR QQILLSFKTAYGKDLIKDLKSELSG NFEKTILALMKTPVLFDIYE IKEAIKGVGTDEACLIEILASRSNE HIRELNRAYKAEFKKTLEEAIRSDT SGHFQRLLISLSQGNRDEST NVDMSLAQRDAQELYAAGENRLGTD ESKFNAVLCSRSRAHLVAVFNEYQR MTGRDIEKSICREMSGDLEE GMLAVVKCLKNTPAFFAERLNKAMR GAGTKDRTLIRIMVSRSETDLLDIR SEYKRMYGKSLYHDISGDTS GDYRKILLKICGGNDTRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Gene Name : | ANXA11 annexin A11 [ Homo sapiens (human) ] |
Official Symbol : | ANXA11 |
Synonyms : | ALS23; ANX11; CAP50; CAP-50; IBMWMA |
Gene ID : | 311 |
mRNA Refseq : | NM_001157.3 |
Protein Refseq : | NP_001148.1 |
MIM : | 602572 |
UniProt ID : | P50995 |
Products Types
◆ Recombinant Protein | ||
ANXA11-580M | Recombinant Mouse ANXA11 Protein, His (Fc)-Avi-tagged | +Inquiry |
Anxa11-606M | Recombinant Mouse Anxa11 Protein, MYC/DDK-tagged | +Inquiry |
ANXA11-343H | Recombinant Human ANXA11 Protein, His (Fc)-Avi-tagged | +Inquiry |
ANXA11-2781H | Recombinant Human ANXA11 protein(291-370 aa), C-His-tagged | +Inquiry |
ANXA11-1712M | Recombinant Mouse ANXA11 Protein | +Inquiry |
◆ Lysates | ||
ANXA11-8836HCL | Recombinant Human ANXA11 293 Cell Lysate | +Inquiry |
ANXA11-8837HCL | Recombinant Human ANXA11 293 Cell Lysate | +Inquiry |
Related Gene
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Customer Reviews (5)
Write a reviewIn addition to its scientific merits, the manufacturer of ANXA11 protein stands out for its outstanding technical support.
Whether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.
The ANXA11 protein offers numerous advantages in trials and research studies, making it an excellent choice for scientists in need of reliable and high-quality experimental materials.
Its unique properties make ANXA11 an invaluable tool for investigating cellular signaling pathways, protein-protein interactions, and membrane dynamics.
The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.
Q&As (12)
Ask a questionYes, ANXA11 has been implicated in various functions within the nervous system. It has been shown to regulate vesicle fusion processes in neuronal synapses, suggesting a role in neurotransmitter release. ANXA11 has also been associated with neuronal differentiation and dendritic branching. Additionally, ANXA11 genetic variants have been linked to neurodegenerative disorders like ALS and FTD, indicating its potential involvement in disease pathogenesis.
Currently, there are no specific inhibitors or activators of ANXA11 that have been widely established. However, certain compounds and agents have been reported to affect ANXA11 function indirectly. For example, calcium ionophores and calcium chelators can modulate ANXA11-mediated calcium signaling. Further research is needed to identify specific molecules that can selectively modulate ANXA11 activity.
ANXA11 has been linked to several diseases and pathological conditions. Certain genetic variations in ANXA11 have been implicated in neurodegenerative disorders like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ANXA11 has also been associated with cancer progression and metastasis in certain tumors, highlighting its potential role in oncogenesis.
Yes, genetic variations and mutations in the ANXA11 gene have been reported. Some studies have identified single nucleotide polymorphisms (SNPs) in ANXA11 associated with specific diseases, such as Alzheimer's disease and bipolar disorder. Rare variants and mutations in ANXA11 have also been implicated in some cases of amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders.
Yes, ANXA11 has been implicated in the regulation of autophagy, a cellular process involved in the degradation and recycling of cellular components. ANXA11 interacts with key autophagy-related proteins, such as beclin-1, Atg5, and LC3, and may be involved in the formation and maturation of autophagic vesicles.
The involvement of ANXA11 in various diseases, particularly ALS and FTD, suggests potential therapeutic implications. Understanding the role of ANXA11 in disease pathogenesis may help in the development of targeted therapies. Additionally, because ANXA11 is involved in membrane trafficking and vesicle fusion processes, it could be a potential target for drug delivery systems. However, more research is needed to fully explore the therapeutic potential of ANXA11.
While ANXA11 has been associated with certain diseases, its utility as a biomarker is still being explored. Studies have suggested that ANXA11 expression levels may have diagnostic and prognostic value in certain cancer types, including breast, lung, and pancreatic cancer. Further research is needed to determine the specific clinical applicability of ANXA11 as a biomarker.
ANXA11 has been implicated in immune response and inflammation processes. It has been shown to regulate the release of pro-inflammatory cytokines, such as interleukin-1 beta (IL-1β), through its involvement in inflammasome signaling pathways. ANXA11 has also been associated with the regulation of immune cell activation and migration. However, further studies are needed to fully elucidate its roles in immune response modulation.
ANXA11 is expressed in a variety of tissues and cell types, but its expression levels may vary depending on the tissue or developmental stage. High levels of ANXA11 expression have been observed in the brain, heart, liver, and kidney, among others. It is also expressed in various cancer types, suggesting a potential role in tumorigenesis.
Yes, ANXA11 is involved in several cellular processes apart from autophagy. It plays a role in membrane trafficking and dynamics, vesicle fusion, calcium signaling, apoptosis regulation, and cellular membrane repair. ANXA11 has also been implicated in cellular processes related to exocytosis, endocytosis, and cellular adhesion.
Yes, ANXA11 interacts with a variety of protein partners in different cellular contexts. Some of its known interacting partners include the SNARE protein SNAP-23, the vesicle-associated protein synaptophysin, the heat shock protein Hsp90, and several components of the endosomal and lysosomal machinery. ANXA11 also interacts with specific miRNAs and RNA-binding proteins, suggesting its involvement in post-transcriptional regulation.
Yes, ANXA11 has been implicated in several diseases. The most well-known association is with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ANXA11 variants have been identified in some familial cases of ALS and FTD, suggesting a genetic susceptibility. ANXA11 has also been linked to cardiovascular diseases, cancer progression, and autoimmune disorders, although more research is needed to fully understand its involvement in these conditions.
Ask a Question for All ANXA11 Products
Required fields are marked with *
My Review for All ANXA11 Products
Required fields are marked with *
Inquiry Basket