Recombinant Full Length Human ARMT1 Protein, GST-tagged
Cat.No. : | ARMT1-2702HF |
Product Overview : | Human ARMT1 full-length ORF (BAB14339.1, 1 a.a. - 441 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | ARMT1 (Acidic Residue Methyltransferase 1) is a Protein Coding gene. GO annotations related to this gene include enzyme binding and protein carboxyl O-methyltransferase activity. |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 77.6 kDa |
Protein Length : | 441 amino acids |
AA Sequence : | MAVVPASLSGQDVGSFAYLTIKDRI PQILTKVIDTLHRHKSEFFEKHGEE GVEAEKKAISLLSKLRNELQTDKPF IPLVEKFVDTDIWNQYLEYQQSLLN ESDGKSRWFYSPWLLVECYMYRRIH EAIIQSPPIDYFDVFKESKEQNFYG SQESIIALCTHLQQLIRTIEDLDEN QLKDEFFKLLQISLWGNKCDLSLSG GESSSQNTNVLNSLEDLKPFILLND MEHLWSLLSNCKKTREKASATRVYI VLDNSGFELVTDLILADFLLSSELA TEVHFYGKTIPWFVSDTTIHDFNWL IEQVKHSNHKWMSKCGADWEEYIKM GKWVYHNHIFWTLPHEYCAMPQVAP DLYAELQKAHLILFKGDLNYRKLTG DRKWEFSVPFHQALNGFHPAPLCTI RTLKAEIQVGLQPGQGEQLLASEPS WWTTGKYGIFQYDGPL |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ARMT1 acidic residue methyltransferase 1 [ Homo sapiens (human) ] |
Official Symbol : | ARMT1 |
Synonyms : | ARMT1; acidic residue methyltransferase 1; C6orf211; CF211_HUMAN; chromosome 6 open reading frame 211; UPF0364 protein C6orf211; |
Gene ID : | 79624 |
mRNA Refseq : | NM_024573 |
Protein Refseq : | NP_078849 |
MIM : | 616332 |
UniProt ID : | Q9H993 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (17)
Ask a questionGenetic variants or mutations in the ARMT1 gene have not been extensively studied or linked to specific diseases. However, genetic variations in the regulatory regions or coding sequence of ARMT1 may potentially contribute to disease susceptibility or altered protein function.
As of now, there are no specific therapeutic interventions targeting ARMT1. However, the growing understanding of its role in various diseases may present opportunities for developing targeted therapies in the future.
Yes, the ARMT1 protein is also referred to as HRMT1-like protein 4 (HCP4) or protein arginine N-methyltransferase 1 (PRMT1). These alternative names can be used interchangeably to describe the same protein.
The ARMT1 protein is involved in various cellular processes. One of its main functions is protein arginine methylation, where it catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to the guanidino nitrogen atom of arginine residues in target proteins. This methylation can impact protein-protein interactions, RNA splicing, chromatin remodeling, and transcriptional regulation.
The activity of the ARMT1 protein can be regulated by various mechanisms. It can be regulated by post-translational modifications such as phosphorylation or by binding to specific cofactors. Additionally, small molecule inhibitors have been developed and used to inhibit the activity of ARMT1 in research settings.
Yes, alternative splicing can generate multiple isoforms of ARMT1 that may have distinct functional properties. These isoforms could exhibit differential tissue-specific expression or modulate specific cellular processes.
Yes, the ARMT1 protein is conserved across many species, including humans and model organisms like mice, rats, and fruit flies. This conservation implies important functional roles throughout evolution.
While more research is needed to fully understand the role of ARMT1 in development, studies in model organisms suggest that it may have important functions during embryonic development, especially in the regulation of gene expression and cell fate determination.
ARMT1 is generally expressed in most cell types and tissues, indicating a broad potential influence in multiple cell types. However, its expression levels may vary among different tissues or during different stages of development.
The ARMT1 protein has been implicated in several disease processes. Dysregulation of its activity has been associated with cancer, neurodegenerative disorders, and cardiovascular diseases. Further research is needed to fully understand the impact of ARMT1 in these diseases.
ARMT1 interacts with various proteins involved in diverse cellular processes, including transcription factors, RNA-binding proteins, chromatin remodelers, and signaling molecules. Specific examples of interacting partners include p53, Sm proteins, histone H4, and STAT3. These interactions suggest that ARMT1 functions in complex regulatory networks within cells.
The ARMT1 protein is primarily localized in the nucleus, where it methylates its target proteins. However, it can also shuttle between the nucleus and the cytoplasm, suggesting additional roles outside of nuclear functions.
The exact protein-protein interactions and molecular pathways involving ARMT1 are not yet fully understood. However, studies have suggested potential interactions with factors involved in chromatin regulation, RNA metabolism, and signal transduction. Ongoing research aims to elucidate these interactions and their functional significance.
The potential use of ARMT1 as a diagnostic or prognostic marker in specific diseases is currently unknown. Further research is needed to determine whether the activity or expression levels of ARMT1 can be clinically utilized in disease diagnosis, prognosis, or monitoring of treatment response.
The ARMT1 protein has been shown to methylate several substrates, including histones, RNA-binding proteins, and transcription factors. It has been implicated in the regulation of gene expression, RNA processing, and cellular signaling.
ARMT1 can be regulated through post-translational modifications, such as phosphorylation or acetylation, which can affect its enzymatic activity or interactions with other proteins. It can also be regulated by the availability of its cofactor, SAM, which serves as the methyl group donor.
The potential therapeutic targeting of ARMT1 is an active area of research. The development of specific inhibitors or activators could help modulate its activity in various disease contexts or provide therapeutic benefits. However, more research is needed to validate these approaches.
Customer Reviews (6)
Write a reviewThe manufacturer also ensures that the ARMT1 protein is well-characterized, with extensive documentation on its functional properties.
One of the key advantages of working with the ARMT1 protein is the comprehensive support provided by its manufacturer.
The ARMT1 protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.
the ARMT1 protein's high quality, stellar technical support, and compatibility with diverse experimental approaches make it an optimal choice for meeting my research needs.
the ARMT1 protein's compatibility with various experimental techniques adds to its versatility.
Whether it's troubleshooting issues, optimizing experimental protocols, or providing detailed information about the protein, the manufacturer's support team is dedicated to helping researchers overcome any challenges they may encounter.
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