Recombinant Full Length Human ARSB Protein, C-Flag-tagged

• Cat.No.: ARSB-1862HFL
• Product Overview: Recombinant Full Length Human ARSB Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 56 kDa
• AA Sequence: MGPRGAASLPRGPGPRRLLLPVVLP LLLLLLLAPPGSGAGASRPPHLVFL LADDLGWNDVGFHGSRIRTP HLDALAAGGVLLDNYYTQPLCTPSR SQLLTGRYQIRTGLQHQIIWPCQPS CVPLDEKLLPQLLKEAGYTT HMVGKWHLGMYRKECLPTRRGFDTY FGYLLGSEDYYSHERCTLIDALNVT RCALDFRDGEEVATGYKNMY STNIFTKRAIALITNHPPEKPLFLY LALQSVHEPLQVPEEYLKPYDFIQD KNRHHYAGMVSLMDEAVGNV TAALKSSGLWNNTVFIFSTDNGGQT LAGGNNWPLRGRKWSLWEGGVRGVG FVASPLLKQKGVKNRELIHI SDWLPTLVKLARGHTNGTKPLDGFD VWKTISEGSPSPRIELLHNIDPNFV DSSPCPRNSMAPAKDDSSLP EYSAFNTSVHAAIRHGNWKLLTGYP GCGYWFPPPSQYNVSEIPSSDPPTK TLWLFDIDRDPEERHDLSRE YPHIVTKLLSRLQFYHKHSVPVYFP AQDPRCDPKATGVWGPWM TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Glycosaminoglycan degradation, Lysosome, Metabolic pathways

Gene Information

• Gene Name: ARSB arylsulfatase B [ Homo sapiens (human) ]
• Official Symbol: ARSB
• Synonyms: ASB; G4S; MPS6
• Gene ID: 411
• mRNA Refseq: NM_000046.5
• Protein Refseq: NP_000037.2
• MIM: 611542
• UniProt ID: P15848