Recombinant Full Length Human CDC23 Protein, GST-tagged

• Cat.No.: CDC23-3134HF
• Product Overview: Human CDC23 full-length ORF (AAH17713, 1 a.a. - 591 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 90.75 kDa
• Protein Length: 591 amino acids
• AA Sequence: MVPVAVTAAVAPVLSINSDFSDLRE IKKQLLLIAGLTRERGLLHSSKWSA ELAFSLPALPLAELQPPPPITEEDA QDMDAYTLAKAYFDVKEYDRAAHFL HGCNSKKAYFLYMYSRYLSGEKKKD DETVDSLGPLEKGQVKNEALRELRV ELSKKHQARELDGFGLYLYGVVLRK LDLVKEAIDVFVEATHVLPLHWGAW LELCNLITDKEMLKFLSLPDTWMKE FFLAHIYTELQLIEEALQKYQNLID VGFSKSSYIVSQIAVAYHNIRDIDK ALSIFNELRKQDPYRIENMDTFSNL LYVRSMKSELSYLAHNLCEIDKYRV ETCCVIGNYYSLRSQHEKAALYFQR ALKLNPRYLGAWTLMGHEYMEMKNT SAAIQAYRHAIEVNKRDYRAWYGLG QTYEILKMPFYCLYYYRRAHQLRPN DSRMLVALGECYEKLNQLVEAKKCY WRAYAVGDVEKMALVKLAKLHEQLT ESEQAAQCYIKYIQDIYSCGEIVEH LEESTAFRYLAQYYFKCKLWDEAST CAQKCCAFNDTREEGKALLRQILQL RNQGETPTTEVPAPFFLPASLSANN TPTRRVSPLNLSSVTP
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CDC23 cell division cycle 23 homolog (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: CDC23
• Synonyms: CDC23; cell division cycle 23 homolog (S. cerevisiae); CDC23 (cell division cycle 23, yeast, homolog); cell division cycle protein 23 homolog; ANAPC8; anaphase promoting complex subunit 8; APC8; CUT23; cyclosome subunit 8; anaphase-promoting complex subunit 8
• Gene ID: 8697
• mRNA Refseq: NM_004661
• Protein Refseq: NP_004652
• MIM: 603462
• UniProt ID: Q9UJX2