Recombinant Full Length Human CDK10 and CCNQ co-expressed Protein, N-GST-tagged

• Cat.No.: CDK10-CCNQ-01HFL
• Product Overview: Recombinant full-length human CDK10 and CyclinM proteins were co-expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.

Specification

• Description: Cyclin-dependent kinase 10 (CDK10) belongs to cdc2 family of kinases and regulates the cell cycle (1). Cyclin M, the only conventional cyclin partner, protects CDK10 from ubiquitin mediated degradation (2). CDK10/cyclinM positively regulates the degradation of ETS2 through phosphorylation of two neighboring serines. EST2 is a transcription factor that plays key roles in cancer and development. CDK10/CyclinM is also known to repress ciliogenesis and to maintain actin cytoskeletan through the phoshorylation of the PKN2 protein kinase and the control of RhoA stability (3).
• Source: Insect cells
• Species: Human
• Tag: N-GST
• Form: Recombinant protein stored in 50mM Tris-HCl,pH 7.5,150mM NaCl,10mM glutathione,0.1mM EDTA,0.25mMDTT,25% glycerol.
• Molecular Mass: 67kDa/52kDa
• Purity: ＞90%
• Storage: Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: >0.05 μg/μl
• Shipping: Product shipped on dry ice.
• Use/Stability: l yr at -70 centigrade from date of shipment.

Gene Information

• Gene Name: CDK10 cyclin dependent kinase 10 [ Homo sapiens (human) ] and CCNQ cyclin Q [ Homo sapiens (human) ]
• Official Symbol: CDK10 and CCNQ
• Synonyms: cyclin dependent kinase 10; ALSAS; PISSLRE; CDK10 and CycM; FAM58A; cyclin Q; CCNQ
• Gene ID: 8558 and 92002
• mRNA Refseq: NM_052988.5 and NM_152274.5
• Protein Refseq: NP_443714.3 and NP_689487.2
• MIM: 603464 and 300708
• UniProt ID: Q15131 and Q8N1B3