Recombinant Full Length Human CRADD Protein, C-Flag-tagged

• Cat.No.: CRADD-1196HFL
• Product Overview: Recombinant Full Length Human CRADD Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 22.6 kDa
• AA Sequence: MEARDKQVLRSLRLELGAEVLVEGL VLQYLYQEGILTENHIQEINAQTTG LRKTMLLLDILPSRGPKAFD TFLDSLQEFPWVREKLKKAREEAMT DLPAGDRLTGIPSHILNSSPSDRQI NQLAQRLGPEWEPMVLSLGL
  SQTDIYRCKANHPHNVQSQVVEAFI RWRQRFGKQATFQSLHNGLRAVEVD PSLLLHMLETRTRPLEQKLISEEDL AANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: CRADD CASP2 and RIPK1 domain containing adaptor with death domain [ Homo sapiens (human) ]
• Official Symbol: CRADD
• Synonyms: MRT34; RAIDD
• Gene ID: 8738
• mRNA Refseq: NM_003805.5
• Protein Refseq: NP_003796.1
• MIM: 603454
• UniProt ID: P78560