Recombinant Full Length Human CSF1R Protein, C-Flag-tagged

• Cat.No.: CSF1R-1085HFL
• Product Overview: Recombinant Full Length Human CSF1R Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 107.8 kDa
• AA Sequence: MGPGVLLLLLVATAWHGQGIPVIEP SVPELVVKPGATVTLRCVGNGSVEW DGPPSPHWTLYSDGSSSILS TNNATFQNTGTYRCTEPGDPLGGSA AIHLYVKDPARPWNVLAQEVVVFED QDALLPCLLTDPVLEAGVSL VRVRGRPLMRHTNYSFSPWHGFTIH RAKFIQSQDYQCSALMGGRKVMSIS IRLKVQKVIPGPPALTLVPA ELVRIRGEAAQIVCSASSVDVNFDV FLQHNNTKLAIHQQSDFHNNRYQKV LTLNLDQVDFQHAGNYSCVA SNVQGKHSTSMFFRVVESAYLNLSS EQNLIQEVTVGEGLNLKVMVEAYPG LQGFNWTYLGPFSDHQPEPK LANVTTKDTYRHTFTLSLPRLKPSE AGRYSFLARNPGGWRALTFELTLRY PPEVSVIWTFINGSGTLLCA ASGYPQPNVTWLQCSGHTDRCDEAQ VLQVWDDPYPEVLSQEPFHKVTVQS LLTVETLEHNQTYECRAHNS VGSGSWAFIPISAGAHTHPPDEFLF TPVVVACMSIMALLLLLLLLLLYKY KQKPKYQVRWKIIESYEGNS YTFIDPTQLPYNEKWEFPRNNLQFG KTLGAGAFGKVVEATAFGLGKEDAV LKVAVKMLKSTAHADEKESL MSELKIMSHLGQHENIVNLLGACTH GGPVLVITEYCCYGDLLNFLRRKAE AMLGPSLSPGQDPEGGVDYK NIHLEKKYVRRDSGFSSQGVDTYVE MRPVSTSSNDSFSEQDLDKEDGRPL ELRDLLHFSSQVAQGMAFLA SKNCIHRDVAARNVLLTNGHVAKIG DFGLARDIMNDSNYIVKGNARLPVK WMAPESIFDCVYTVQSDVWS YGILLWEIFSLGLNPYPGILVNSKF YKLVKDGYQMAQPAFAPKNIYSIMQ ACWALEPTHRPTFQQICSFL
  QEQAQEDRRERDYTNLPSSSRSGGS GSSSSELEEESSSEHLTCCEQGDIA QPLLQPNNYQFCTRTRPLEQKLISE EDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Pathways in cancer

Gene Information

• Gene Name: CSF1R colony stimulating factor 1 receptor [ Homo sapiens (human) ]
• Official Symbol: CSF1R
• Synonyms: FMS; CSFR; FIM2; HDLS; C-FMS; CD115; HDLS1; CSF-1R; BANDDOS; M-CSF-R
• Gene ID: 1436
• mRNA Refseq: NM_005211.4
• Protein Refseq: NP_005202.2
• MIM: 164770
• UniProt ID: P07333