Recombinant Full Length Human CSNK1E Protein, C-Flag-tagged

• Cat.No.: CSNK1E-764HFL
• Product Overview: Recombinant Full Length Human CSNK1E Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 47.1 kDa
• AA Sequence: MELRVGNKYRLGRKIGSGSFGDIYL GANIASGEEVAIKLECVKTKHPQLH IESKFYKMMQGGVGIPSIKW CGAEGDYNVMVMELLGPSLEDLFNF CSRKFSLKTVLLLADQMISRIEYIH SKNFIHRDVKPDNFLMGLGK KGNLVYIIDFGLAKKYRDARTHQHI PYRENKNLTGTARYASINTHLGIEQ SRRDDLESLGYVLMYFNLGS LPWQGLKAATKRQKYERISEKKMST PIEVLCKGYPSEFSTYLNFCRSLRF DDKPDYSYLRQLFRNLFHRQ GFSYDYVFDWNMLKFGAARNPEDVD RERREHEREERMGQLRGSATRALPP GPPTGATANRLRSAAEPVAS TPASRIQPAGNTSPRAISRVDRERK VSMRLHRGAPANVSSSDLTGRQEVS RIPASQTSVPFDHLGKTRTRPLEQK LISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Circadian rhythm - mammal, Hedgehog signaling pathway, Wnt signaling pathway

Gene Information

• Gene Name: CSNK1E casein kinase 1 epsilon [ Homo sapiens (human) ]
• Official Symbol: CSNK1E
• Synonyms: CKIe; HCKIE; CKIepsilon
• Gene ID: 1454
• mRNA Refseq: NM_152221.3
• Protein Refseq: NP_689407.1
• MIM: 600863
• UniProt ID: P49674