Recombinant Full Length Human DR1 Protein, GST-tagged

• Cat.No.: DR1-4179HF
• Product Overview: Human DR1 full-length ORF ( AAH02809, 1 a.a. - 176 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 45.10 kDa
• Protein Length: 176 amino acids
• AA Sequence: MASSSGNDDDLTIPRAAINKMIKET LPNVRVANDARELVVNCCTEFIHLI SSEANEICNKSEKKTISPEHVIQAL ESLGFGSYISEVKEVLQECKTVALK RRKASSRLENLGIPEEELLRQQQEL FAKARQQQAELAQQEWLQMQQAAQQ AQLAAASASASNQAGSSQDEEDDDD I
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) [ Homo sapiens ]
• Official Symbol: DR1
• Synonyms: DR1; down-regulator of transcription 1, TBP-binding (negative cofactor 2); protein Dr1; NC2; NC2 BETA; negative cofactor 2-beta; TATA-binding protein-associated phosphoprotein; NC2-BETA
• Gene ID: 1810
• mRNA Refseq: NM_001938
• Protein Refseq: NP_001929
• MIM: 601482
• UniProt ID: Q01658