Recombinant Full Length Human ERC1 Protein, C-Flag-tagged

• Cat.No.: ERC1-806HFL
• Product Overview: Recombinant Full Length Human ERC1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 127.9 kDa
• AA Sequence: MYGSARSVGKVEPSSQSPGRSPRLP RSPRLGHRRTNSTGGSSGSSVGGGS GKTLSMENIQSLNAAYATSG PMYLSDHENVGSETPKSTMTLGRSG GRLPYGVRMTAMGSSPNIASSGVAS DTIAFGEHHLPPVSMASTVP HSLRQARDNTIMDLQTQLKEVLREN DLLRKDVEVKESKLSSSMNSIKTFW SPELKKERALRKDEASKITI WKEQYRVVQEENQHMQMTIQALQDE LRIQRDLNQLFQQDSSSRTGEPCVA ELTEENFQRLHAEHERQAKE LFLLRKTLEEMELRIETQKQTLNAR DESIKKLLEMLQSKGLSAKATEEDH ERTRRLAEAEMHVHHLESLL EQKEKENSMLREEMHRRFENAPDSA KTKALQTVIEMKDSKISSMERGLRD LEEEIQMLKSNGALSTEERE EEMKQMEVYRSHSKFMKNKVEQLKE ELSSKEAQWEELKKKAAGLQAEIGQ VKQELSRKDTELLALQTKLE TLTNQFSDSKQHIEVLKESLTAKEQ RAAILQTEVDALRLRLEEKETMLNK KTKQIQDMAEEKGTQAGEIH DLKDMLDVKERKVNVLQKKIENLQE QLRDKEKQMSSLKERVKSLQADTTN TDTALTTLEEALAEKERTIE RLKEQRDRDEREKQEEIDNYKKDLK DLKEKVSLLQGDLSEKEASLLDLKE HASSLASSGLKKDSRLKTLE IALEQKKEECLKMESQLKKAHEAAL EARASPEMSDRIQHLEREITRYKDE SSKAQAEVDRLLEILKEVEN EKNDKDKKIAELERQVKDQNKKVAN LKHKEQVEKKKSAQMLEEARRREDN LNDSSQQLQDSLRKKDDRIE ELEEALRESVQITAEREMVLAQEES ARTNAEKQVEELLMAMEKVKQELES MKAKLSSTQQSLAEKETHLT NLRAERRKHLEEVLEMKQEALLAAI SEKDANIALLELSSSKKKTQEEVAA LKREKDRLVQQLKQQTQNRM KLMADNYEDDHFKSSHSNQTNHKPS PDQIIQPLLELDQNRSKLKLYIGHL TTLCHDRDPLILRGLTPPAS YNLDDDQAAWENELQKMTRGQLQDE LEKGERDNAELQEFANAILQQIADH CPDILEQVVNALEESSTRTRPLEQK LISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: ERC1 ELKS/RAB6-interacting/CAST family member 1 [ Homo sapiens (human) ]
• Official Symbol: ERC1
• Synonyms: ELKS; Cast2; ERC-1; RAB6IP2
• Gene ID: 23085
• mRNA Refseq: NM_178040.4
• Protein Refseq: NP_829884.1
• MIM: 607127
• UniProt ID: Q8IUD2