Recombinant Full Length Human ERCC4 Protein, C-Flag-tagged

• Cat.No.: ERCC4-1928HFL
• Product Overview: Recombinant Full Length Human ERCC4 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 104.3 kDa
• AA Sequence: MESGQPARRIAMAPLLEYERQLVLE LLDTDGLVVCARGLGADRLLYHFLQ LHCHPACLVLVLNTQPAEEE YFINQLKIEGVEHLPRRVTNEITSN SRYEVYTQGGVIFATSRILVVDFLT DRIPSDLITGILVYRAHRII ESCQEAFILRLFRQKNKRGFIKAFT DNAVAFDTGFCHVERVMRNLFVRKL YLWPRFHVAVNSFLEQHKPE VVEIHVSMTPTMLAIQTAILDILNA CLKELKCHNPSLEVEDLSLENAIGK PFDKTIRHYLDPLWHQLGAK TKSLVQDLKILRTLLQYLSQYDCVT FLNLLESLRATEKAFGQNSGWLFLD SSTSMFINARARVYHLPDAK MSKKEKISEKMEIKEGEETKKELVL ESNPKWEALTEVLKEIEAENKESEA LGGPGQVLICASDDRTCSQL RDYITLGAEAFLLRLYRKTFEKDSK AEEVWMKFRKEDSSKRIRKSHKRPK DPQNKERASTKERTLKKKKR KLTLTQMVGKPEELEEEGDVEEGYR REISSSPESCPEEIKHEEFDVNLSS DAAFGILKEPLTIIHPLLGC SDPYALTRVLHEVEPRYVVLYDAEL TFVRQLEIYRASRPGKPLRVYFLIY GGSTEEQRYLTALRKEKEAF EKLIREKASMVVPEEREGRDETNLD LVRGTASADVSTDTRKAGGQEQNGT QQSIVVDMREFRSELPSLIH RRGIDIEPVTLEVGDYILTPEMCVE RKSISDLIGSLNNGRLYSQCISMSR YYKRPVLLIEFDPSKPFSLT SRGALFQEISSNDISSKLTLLTLHF PRLRILWCPSPHATAELFEELKQSK PQPDAATALAITADSETLPE SEKYNPGPQDFLLKMPGVNAKNCRS LMHHVKNIAELAALSQDELTSILGN AANAKQLYDFIHTSFAEVVS KGKGKK TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Nucleotide excision repair

Gene Information

• Gene Name: ERCC4 ERCC excision repair 4, endonuclease catalytic subunit [ Homo sapiens (human) ]
• Official Symbol: ERCC4
• Synonyms: ERCC11, FANCQ, RAD1, XFEPS, XPF
• Gene ID: 2072
• mRNA Refseq: NM_005236.3
• Protein Refseq: NP_005227.1
• MIM: 133520
• UniProt ID: Q92889