Recombinant Full Length Human FDPS Protein, GST-tagged

• Cat.No.: FDPS-4775HF
• Product Overview: Human FDPS full-length ORF ( NP_001995.1, 1 a.a. - 419 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 74.7 kDa
• Protein Length: 419 amino acids
• AA Sequence: MPLSRWLRSVGVFLLPAPYWAPRER WLGSLRRPSLVHGYPVLAWHSARCW CQAWTEEPRALCSSLRMNGDQNSDV YAQEKQDFVQHFSQIVRVLTEDEMG HPEIGDAIARLKEVLEYNAIGGKYN RGLTVVVAFRELVEPRKQDADSLQR AWTVGWCVELLQAFFLVADDIMDSS LTRRGQICWYQKPGVGLDAINDANL LEACIYRLLKLYCREQPYYLNLIEL FLQSSYQTEIGQTLDLLTAPQGNVD LVRFTEKRYKSIVKYKTAFYSFYLP IAAAMYMAGIDGEKEHANAKKILLE MGEFFQIQDDYLDLFGDPSVTGKIG TDIQDNKCSWLVVQCLQRATPEQYQ ILKENYGQKEAEKVARVKALYEELD LPAVFLQYEEDSYSHIMALIEQYAA PLPPAVFLGLARKIYKRRK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FDPS farnesyl diphosphate synthase [ Homo sapiens ]
• Official Symbol: FDPS
• Synonyms: FDPS; farnesyl diphosphate synthase; farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase; dimethylallyltranstransferase; geranyltranstransferase; FPP synthase; FPP synthetase; (2E,6E)-farnesyl diphosphate synthase; farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase; FPS; FPPS
• Gene ID: 2224
• mRNA Refseq: NM_001135821
• Protein Refseq: NP_001129293
• MIM: 134629
• UniProt ID: P14324