Recombinant Full Length Human FIG4 Protein, GST-tagged

• Cat.No.: FIG4-5104HF
• Product Overview: Human FIG4 full-length ORF ( NP_055660.1, 1 a.a. - 907 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 130 kDa
• Protein Length: 907 amino acids
• AA Sequence: MPTAAAPIISSVQKLVLYETRARYF LVGSNNAETKYRVLKIDRTEPKDLV IIDDRHVYTQQEVRELLGRLDLGNR TKMGQKGSSGLFRAVSAFGVVGFVR FLEGYYIVLITKRRKMADIGGHAIY KVEDTNMIYIPNDSVRVTHPDEARY LRIFQNVDLSSNFYFSYSYDLSHSL QYNLTVLRMPLEMLKSEMTQNRQES FDIFEDEGLITQGGSGVFGICSEPY MKYVWNGELLDIIKSTVHRDWLLYI IHGFCGQSKLLIYGRPVYVTLIARR SSKFAGTRFLKRGANCEGDVANEVE TEQILCDASVMSFTAGSYSSYVQVR GSVPLYWSQDISTMMPKPPITLDQA DPFAHVAALHFDQMFQRFGSPIIIL NLVKEREKRKHERILSEELVAAVTY LNQFLPPEHTIVYIPWDMAKYTKSK LCNVLDRLNVIAESVVKKTGFFVNR PDSYCSILRPDEKWNELGGCVIPTG RLQTGILRTNCVDCLDRTNTAQFMV GKCALAYQLYSLGLIDKPNLQFDTD AVRLFEELYEDHGDTLSLQYGGSQL VHRVKTYRKIAPWTQHSKDIMQTLS RYYSNAFSDADRQDSINLFLGVFHP TEGKPHLWELPTDFYLHHKNTMRLL PTRRSYTYWWTPEVIKHLPLPYDEV ICAVNLKKLIVKKFHKYEEEIDIHN EFFRPYELSSFDDTFCLAMTSSARD FMPKTVGIDPSPFTVRKPDETGKSV LGNKSNREEAVLQRKTAASAPPPPS EEAVSSSSEDDSGTDREEEGSVSQR STPVKMTDAGDSAKVTENVVQPMKE LYGINLSDGLSEEDFSIYSRFVQLG QSQHKQDKNSQQPCSRCSDGVIKLT PISAFSQDNIYEVQPPRVDRKSTEI FQAHIQASQGIMQPLGKEDSSMYRE YIRNRYL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FIG4 FIG4 phosphoinositide 5-phosphatase [ Homo sapiens (human) ]
• Official Symbol: FIG4
• Synonyms: FIG4; FIG4 phosphoinositide 5-phosphatase; YVS; BTOP; SAC3; ALS11; CMT4J; KIAA0274; dJ249I4.1; polyphosphoinositide phosphatase; FIG4 homolog, SAC domain containing lipid phosphatase; FIG4 homolog, SAC1 domain containing lipid phosphatase; FIG4 homolog, SAC1 lipid phosphatase domain containing; SAC domain-containing protein 3; Sac domain-containing inositol phosphatase 3; phosphatidylinositol 3,5-bisphosphate 5-phosphatase
• Gene ID: 9896
• mRNA Refseq: NM_014845
• Protein Refseq: NP_055660
• MIM: 609390
• UniProt ID: Q92562