Recombinant Full Length Human FLRT2 Protein, C-Flag-tagged

• Cat.No.: FLRT2-70HFL
• Product Overview: Recombinant Full Length Human FLRT2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 73.9 kDa
• AA Sequence: MGLQTTKWPSHGAFFLKSWLIISLG LYSQVSKLLACPSVCRCDRNFVYCN ERSLTSVPLGIPEGVTVLYL HNNQINNAGFPAELHNVQSVHTVYL YGNQLDEFPMNLPKNVRVLHLQENN IQTISRAALAQLLKLEELHL DDNSISTVGVEDGAFREAISLKLLF LSKNHLSSVPVGLPVDLQELRVDEN RIAVISDMAFQNLTSLERLI VDGNLLTNKGIAEGTFSHLTKLKEF SIVRNSLSHPPPDLPGTHLIRLYLQ DNQINHIPLTAFSNLRKLER LDISNNQLRMLTQGVFDNLSNLKQL TARNNPWFCDCSIKWVTEWLKYIPS SLNVRGFMCQGPEQVRGMAV RELNMNLLSCPTTTPGLPLFTPAPS TASPTTQPPTLSIPNPSRSYTPPTP TTSKLPTIPDWDGRERVTPP ISERIQLSIHFVNDTSIQVSWLSLF TVMAYKLTWVKMGHSLVGGIVQERI VSGEKQHLSLVNLEPRSTYR ICLVPLDAFNYRAVEDTICSEATTH ASYLNNGSNTASSHEQTTSHSMGSP FLLAGLIGGAVIFVLVVLLS VFCWHMHKKGRYTSQKWKYNRGRRK DDYCEAGTKKDNSILEMTETSFQIV SLNNDQLLKGDFRLQPIYTP
  NGGINYTDCHIPNNMRYCNSSVPDL EHCHTTRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane

Gene Information

• Gene Name: FLRT2 fibronectin leucine rich transmembrane protein 2 [ Homo sapiens (human) ]
• Official Symbol: FLRT2
• Synonyms: KIAA0405
• Gene ID: 23768
• mRNA Refseq: NM_013231.6
• Protein Refseq: NP_037363.1
• MIM: 604807
• UniProt ID: O43155