| Description : |
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Form : |
Liquid |
| Molecular Mass : |
90.420kDa inclusive of tags |
| Protein Length : |
585 amino acids |
| AA Sequence : |
MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGI GNKLCALLYGDAEKPAESGGSQPPRAAARKAACACDQK PCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNIL LQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNL EEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWL TSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGS GDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLI AFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIP SDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVAD ICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSV TWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQD KHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFE AHVDKCLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWY IPPSLRTLEDNEERMSRLSKVAPVIKARMMEYGTTMVS YQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL |
| Purity : |
Proprietary Purification |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles. |
| Storage Buffer : |
pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione. |
