Recombinant Full Length Human GAD2 Protein

• Cat.No.: GAD2-185HF
• Product Overview: Recombinant full length Human GAD65 with N terminal proprietary tag; Predicted MWt 90.42 kDa.

Specification

• Species: Human
• Source: In Vitro Cell Free System
• Protein Length: 585 amino acids
• Description: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
• Form: Liquid
• Molecular Mass: 90.420kDa inclusive of tags
• AA Sequence: MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGI GNKLCALLYGDAEKPAESGGSQPPRAAARKAACACDQK PCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNIL LQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNL EEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWL TSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGS GDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLI AFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIP SDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVAD ICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSV TWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQD KHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFE AHVDKCLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWY IPPSLRTLEDNEERMSRLSKVAPVIKARMMEYGTTMVS YQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione.

Gene Information

• Gene Name: GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) [ Homo sapiens ]
• Official Symbol: GAD2
• Synonyms: GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); glutamate decarboxylase 2 (pancreatic islets and brain, 65kD); glutamate decarboxylase 2; GAD65
• Gene ID: 2572
• mRNA Refseq: NM_000818
• Protein Refseq: NP_000809
• MIM: 138275
• UniProt ID: Q05329