Recombinant Full Length Human GARS Protein, His tagged

• Cat.No.: GARS-12HFL
• Product Overview: Recombinant Full Length Human GARS Protein fused to adeca-histidine purification tag was expressed in Spodoptera frugiperda Sf9 insectcells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Protein Length: 1-739 aa
• Description: This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Two transcript variants encoding different isoforms have been found for this gene.
• Immunological function: Binds lgG-type human auto-antibodies.
• Molecular Mass: 79 kDa
• Bio-activity: SDS-PAGE; Western blot with i: anti-EJ autoantibody-positive sample; ii: monoclonal anti-His-tag antibody.
• Calculated isoelectric point: pH 6.17
• Immunological tests/Functionality: Immunodot analyses with positive/negative samples.
• Purity: >80%
• Storage: At -70 centigrade or below. Repeated freeze/thaw cycles should be avoided.
• Storage Buffer: Neutral to slightly alkaline pH and 20% glycerol as cryoprotective aqent.

Gene Information

• Gene Name: GARS1 glycyl-tRNA synthetase 1 [ Homo sapiens (human) ]
• Official Symbol: GARS1
• Synonyms: GARS1; glycyl-tRNA synthetase 1; GARS; HMN5; CMT2D; DSMAV; GlyRS; HMN5A; HMND5; SMAD1; SMAJI; glycine--tRNA ligase; AP-4-A synthetase; Charcot-Marie-Tooth neuropathy 2D; Charcot-Marie-Tooth neuropathy, neuronal type, D; ap4A synthetase; diadenosine tetraphosphate synthetase; EC 6.1.1.14
• Gene ID: 2617
• mRNA Refseq: NM_002047
• Protein Refseq: NP_002038
• MIM: 600287
• UniProt ID: P41250