Recombinant Full Length Human GPHN Protein, C-Flag-tagged

• Cat.No.: GPHN-873HFL
• Product Overview: Recombinant Full Length Human GPHN Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 83.3 kDa
• AA Sequence: MATEGMILTNHDHQIRVGVLTVSDS CFRNLAEDRSGINLKDLVQDPSLLG GTISAYKIVPDEIEEIKETL IDWCDEKELNLILTTGGTGFAPRDV TPEATKEVIEREAPGMALAMLMGSL NVTPLGMLSRPVCGIRGKTL IINLPGSKKGSQECFQFILPALPHA IDLLRDAIVKVKEVHDELEDLPSPP PPLSPPPTTSPHKQTEDKGV QCEEEEEEKKDSGVASTEDSSSSHI TAAAIAAKKHPFYTSPAVVMAHGEQ PIPGLINYSHHSTDERIPDS IISRGVQVLPRDTASLSTTPSESPR AQATSRLSTASCPTPKVQSRCSSKE NILRASHSAVDITKVARRHR MSPFPLTSMDKAFITVLEMTPVLGT EIINYRDGMGRVLAQDVYAKDNLPP FPASVKDGYAVRAADGPGDR FIIGESQAGEQPTQTVMPGQVMRVT TGAPIPCGADAVVQVEDTELIRESD DGTEELEVRILVQARPGQDI RPIGHDIKRGECVLAKGTHMGPSEI GLLATVGVTEVEVNKFPVVAVMSTG NELLNPEDDLLPGKIRDSNR STLLATIQEHGYPTINLGIVGDNPD DLLNALNEGISRADVIITSGGVSMG EKDYLKQVLDIDLHAQIHFG RVFMKPGLPTTFATLDIDGVRKIIF ALPGNPVSAVVTCNLFVVPALRKMQ GILDPRPTIIKARLSCDVKL DPRPEYHRCILTWHHQEPLPWAQST GNQMSSRLMSMRSANGLLMLPPKTE QYVELHKGEVVDVMVIGRLTRTRPL EQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: GPHN gephyrin [ Homo sapiens (human) ]
• Official Symbol: GPHN
• Synonyms: GPH; GEPH; HKPX1; GPHRYN; MOCODC
• Gene ID: 10243
• mRNA Refseq: NM_020806.5
• Protein Refseq: NP_065857.1
• MIM: 603930
• UniProt ID: Q9NQX3