Recombinant Full Length Human HNRNPK Protein, GST-tagged

• Cat.No.: HNRNPK-3684HF
• Product Overview: Human HNRPK full-length ORF ( NP_112552.1, 1 a.a. - 463 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 77.4 kDa
• Protein Length: 463 amino acids
• AA Sequence: METEQPEETFPNTETNGEFGKRPAE DMEEEQAFKRSRNTDEMVELRILLQ SKNAGAVIGKGGKNIKALRTDYNAS VSVPDSSGPERILSISADIETIGEI LKKIIPTLEEGLQLPSPTATSQLPL ESDAVECLNYQHYKGSDFDCELRLL IHQSLAGGIIGVKGAKIKELRENTQ TTIKLFQECCPHSTDRVVLIGGKPD RVVECIKIILDLISESPIKGRAQPY DPNFYDETYDYGGFTMMFDDRRGRP VGFPMRGRGGFDRMPPGRGGRPMPP SRRDYDDMSPRRGPPPPPPGRGGRG GSRARNLPLPPPPPPRGGDLMAYDR RGRPGDRYDGMVGFSADETWDSAID TWSPSEWQMAYEPQGGSGYDYSYAG GRGSYGDLGGPIITTQVTIPKDLAG SIIGKGGQRIKQIRHESGASIKIDE PLEGSEDRIITITGTQDQIQNAQYL LQNSVKQYSGKFF
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: HNRNPK heterogeneous nuclear ribonucleoprotein K [ Homo sapiens ]
• Official Symbol: HNRNPK
• Synonyms: HNRNPK; heterogeneous nuclear ribonucleoprotein K; HNRPK; CSBP; transformation upregulated nuclear protein; TUNP; dC-stretch binding protein; FLJ41122
• Gene ID: 3190
• mRNA Refseq: NM_002140
• Protein Refseq: NP_002131
• MIM: 600712
• UniProt ID: P61978