Recombinant Full Length Human IFNA1 Protein, C-Flag-tagged

• Cat.No.: IFNA1-1816HFL
• Product Overview: Recombinant Full Length Human IFNA1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. This cytokine is upregulated in preeclamptic placentas and is thought to be a mediator of preeclampsia.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 19.3 kDa
• AA Sequence: MASPFALLMALVVLSCKSSCSLGCD LPETHSLDNRRTLMLLAQMSRISPS SCLMDRHDFGFPQEEFDGNQ FQKAPAISVLHELIQQIFNLFTTKD SSAAWDEDLLDKFCTELYQQLNDLE ACVMQEERVGETPLMNADSI LAVKKYFRRITLYLTEKKYSPCAWE VVRAEIMRSLSLSTNLQERLRRKE TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Antigen processing and presentation, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Regulation of autophagy, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway

Gene Information

• Gene Name: IFNA1 interferon alpha 1 [ Homo sapiens (human) ]
• Official Symbol: IFNA1
• Synonyms: IFL; IFN; IFNA@; IFNA13; leIF D; IFN-ALPHA; IFN-alphaD
• Gene ID: 3439
• mRNA Refseq: NM_024013.3
• Protein Refseq: NP_076918.1
• MIM: 147660
• UniProt ID: P01562