Recombinant Full Length Human IL2RB Protein

• Cat.No.: IL2RB-5757HF
• Product Overview: Human IL2RB full-length ORF (NP_000869.1) recombinant protein without tag.

Specification

• Description: The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 61.1 kDa
• Protein Length: 963 amino acids
• AA Sequence: MAAPALSWRLPLLILLLPLATSWAS AAVNGTSQFTCFYNSRANISCVWSQ DGALQDTSCQVHAWPDRRRWNQTCE LLPVSQASWACNLILGAPDSQKLTT VDIVTLRVLCREGVRWRVMAIQDFK PFENLRLMAPISLQVVHVETHRCNI SWEISQASHYFERHLEFEARTLSPG HTWEEAPLLTLKQKQEWICLETLTP DTQYEFQVRVKPLQGEFTTWSPWSQ PLAFRTKPAALGKDTIPWLGHLLVG LSGAFGFIILVYLLINCRNTGPWLK KVLKCNTPDPSKFFSQLSSEHGGDV QKWLSSPFPSSSFSPGGLAPEISPL EVLERDKVTQLLLQQDKVPEPASLS SNHSLTSCFTNQGYFFFHLPDALEI EACQVYFTYDPYSEEDPDEGVAGAP TGSSPQPLQPLSGEDDAYCTFPSRD DLLLFSPSLLGGPSPPSTAPGGSGA GEERMPPSLQERVPRDWDPQPLGPP TPGVPDLVDFQPPPELVLREAGEEV PDAGPREGVSFPWSRPPGQGEFRAL NARLPLNTDAYLSLQELQGQDPTHL V
• Applications: Antibody Production
  Functional Study
  Compound Screening
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.

Gene Information

• Gene Name: IL2RB interleukin 2 receptor, beta [ Homo sapiens ]
• Official Symbol: IL2RB
• Synonyms: IL2RB; interleukin 2 receptor, beta; IL15RB, interleukin 15 receptor, beta; interleukin-2 receptor subunit beta; CD122; p75; IL-2RB; CD122 antigen; IL-2R subunit beta; IL-2 receptor subunit beta; interleukin 15 receptor, beta; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; IL15RB; P70-75
• Gene ID: 3560
• mRNA Refseq: NM_000878
• Protein Refseq: NP_000869
• MIM: 146710
• UniProt ID: P14784