Recombinant Full Length Human KPNA6 Protein, C-Flag-tagged

• Cat.No.: KPNA6-1696HFL
• Product Overview: Recombinant Full Length Human KPNA6 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 59.8 kDa
• AA Sequence: METMASPGKDNYRMKSYKNNALNPE EMRRRREEEGIQLRKQKREQQLFKR RNVELINEEAAMFDSLLMDS YVSSTTGESVITREMVEMLFSDDSD LQLATTQKFRKLLSKEPSPPIDEVI NTPRVVDRFVEFLKRNENCT LQFEAAWALTNIASGTSQQTKIVIE AGAVPIFIELLNSDFEDVQEQAVWA LGNIAGDSSVCRDYVLNCSI LNPLLTLLTKSTRLTMTRNAVWALS NLCRGKNPPPEFAKVSPCLPVLSRL LFSSDSDLLADACWALSYLS DGPNEKIQAVIDSGVCRRLVELLMH NDYKVASPALRAVGNIVTGDDIQTQ VILNCSALPCLLHLLSSPKE SIRKEACWTISNITAGNRAQIQAVI DANIFPVLIEILQKAEFRTRKEAAW AITNATSGGTPEQIRYLVSL GCIKPLCDLLTVMDSKIVQVALNGL ENILRLGEQEGKRSGSGVNPYCGLI EEAYGLDKIEFLQSHENQEI
  YQKAFDLIEHYFGVEDDDSSLAPQV DETQQQFIFQQPEAPMEGFQLTRTR PLEQKLISEEDLAANDILDYKDDDD KV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: KPNA6 karyopherin subunit alpha 6 [ Homo sapiens (human) ]
• Official Symbol: KPNA6
• Synonyms: IPOA7
• Gene ID: 23633
• mRNA Refseq: NM_012316.5
• Protein Refseq: NP_036448.1
• MIM: 610563
• UniProt ID: O60684