Recombinant Full Length Human LTA4H Protein, C-Flag-tagged

• Cat.No.: LTA4H-1096HFL
• Product Overview: Recombinant Full Length Human LTA4H Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 69.1 kDa
• AA Sequence: MPEIVDTCSLASPASVCRTKHLHLR CSVDFTRRTLTGTAALTVQSQEDNL RSLVLDTKDLTIEKVVINGQ EVKYALGERQSYKGSPMEISLPIAL SKNQEIVIEISFETSPKSSALQWLT PEQTSGKEHPYLFSQCQAIH CRAILPCQDTPSVKLTYTAEVSVPK ELVALMSAIRDGETPDPEDPSRKIY KFIQKVPIPCYLIALVVGAL ESRQIGPRTLVWSEKEQVEKSAYEF SETESMLKIAEDLGGPYVWGQYDLL VLPPSFPYGGMENPCLTFVT PTLLAGDKSLSNVIAHEISHSWTGN LVTNKTWDHFWLNEGHTVYLERHIC GRLFGEKFRHFNALGGWGEL QNSVKTFGETHPFTKLVVDLTDIDP DVAYSSVPYEKGFALLFYLEQLLGG PEIFLGFLKAYVEKFSYKSI TTDDWKDFLYSYFKDKVDVLNQVDW NAWLYSPGLPPIKPNYDMTLTNACI ALSQRWITAKEDDLNSFNAT DLKDLSSHQLNEFLAQTLQRAPLPL GHIKRMQEVYNFNAINNSEIRFRWL RLCIQSKWEDAIPLALKMAT
  EQGRMKFTRPLFKDLAAFDKSHDQA VRTYQEHKASMHPVTAMLVGKDLKV DTRTRPLEQKLISEEDLAANDILDY KDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protease
• Protein Pathways: Arachidonic acid metabolism, Metabolic pathways

Gene Information

• Gene Name: LTA4H leukotriene A4 hydrolase [ Homo sapiens (human) ]
• Official Symbol: LTA4H
• Synonyms: leukotriene A4 hydrolase
• Gene ID: 4048
• mRNA Refseq: NM_000895.3
• Protein Refseq: NP_000886.1
• MIM: 151570
• UniProt ID: P09960