Recombinant Full Length Human MC2R Protein, C-Flag-tagged

• Cat.No.: MC2R-1483HFL
• Product Overview: Recombinant Full Length Human MC2R Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 33.7 kDa
• AA Sequence: MKHIINSYENINNTARNNSDCPRVV LPEEIFFTISIVGVLENLIVLLAVF KNKNLQAPMYFFICSLAISD MLGSLYKILENILIILRNMGYLKPR GSFETTADDIIDSLFVLSLLGSIFS LSVIAADRYITIFHALRYHS IVTMRRTVVVLTVIWTFCTGTGITM VIFSHHVPTVITFTSLFPLMLVFIL CLYVHMFLLARSHTRKISTL PRANMKGAITLTILLGVFIFCWAPF VLHVLLMTFCPSNPYCACYMSLFQV NGMLIMCNAVIDPFIYAFRS
  PELRDAFKKMIFCSRYWTRTRPLEQ KLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction

Gene Information

• Gene Name: MC2R melanocortin 2 receptor [ Homo sapiens (human) ]
• Official Symbol: MC2R
• Synonyms: ACTHR
• Gene ID: 4158
• mRNA Refseq: NM_000529.2
• Protein Refseq: NP_000520.1
• MIM: 607397
• UniProt ID: Q01718