Recombinant Full Length Human MCM7 Protein
| Cat.No. : | MCM7-300HF |
| Product Overview : | Recombinant full length Human MCM7 with N terminal proprietary tag; Predicted MWt 68.90 kDa. |
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| Species : | Human |
| Source : | In Vitro Cell Free System |
| Protein Length : | 389 amino acids |
| Description : | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Form : | Liquid |
| Molecular Mass : | 68.900kDa inclusive of tags |
| AA Sequence : | MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRL AHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADA VQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVR SPQNQYPAELMRRFELYFQGPSSSKPRVIREVRADSVGKL VTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTF MPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEH SDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPI LRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELT REELRQIADVIFATVRELVSGGRSVRFSEAEQRCVSRGFT PAQFQAALDEYEELNVWQVNASRTRITFV |
| Purity : | Proprietary Purification |
| Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles. |
| Storage Buffer : | pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione. |
| Gene Name | MCM7 minichromosome maintenance complex component 7 [ Homo sapiens ] |
| Official Symbol | MCM7 |
| Synonyms | MCM7; minichromosome maintenance complex component 7; MCM2, MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) , minichromosome maintenance deficient (S. cerevisiae) 7; DNA replication licensing factor MCM7; CDC47 |
| Gene ID | 4176 |
| mRNA Refseq | NM_005916 |
| Protein Refseq | NP_005907 |
| MIM | 600592 |
| UniProt ID | P33993 |
Not For Human Consumption!
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