Recombinant Full Length Human MEN1 Protein, C-Flag-tagged

• Cat.No.: MEN1-229HFL
• Product Overview: Recombinant Full Length Human MEN1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 67.3 kDa
• AA Sequence: MGLKAAQKTLFPLRSIDDVVRLFAA ELGREEPDLVLLSLVLGFVEHFLAV NRVIPTNVPELTFQPSPAPD PPGGLTYFPVADLSIIAALYARFTA QIRGAVDLSLYPREGGVSSRELVKK VSDVIWNSLSRSYFKDRAHI QSLFSFITGTKLDSSGVAFAVVGAC QALGLRDVHLALSEDHAWVVFGPNG EQTAEVTWHGKGNEDRRGQT VNAGVAERSWLYLKGSYMRCDRKME VAFMVCAINPSIDLHTDSLELLQLQ QKLLWLLYDLGHLERYPMAL GNLADLEELEPTPGRPDPLTLYHKG IASAKTYYRDEHIYPYMYLAGYHCR NRNVREALQAWADTATVIQD YNYCREDEEIYKEFFEVANDVIPNL LKEAASLLEAGEERPGEQSQGTQSQ GSALQDPECFAHLLRFYDGI CKWEEGSPTPVLHVGWATFLVQSLG RFEGQVRQKVRIVSREAEAAEAEEP WGEEAREGRRRGPRRESKPE EPPPPKKPALDKGLGTGQGAVSGPP RKPPGTVAGTARGPEGGSTAQVPAP AASPPPEGPVLTFQSEKMKG
  MKELLVATKINSSAIKLQLTAQSQV QMKKQKVSTPSDYTLSFLKRQRKGL TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transcription Factors

Gene Information

• Gene Name: MEN1 menin 1 [ Homo sapiens (human) ]
• Official Symbol: MEN1
• Synonyms: MEAI; SCG2
• Gene ID: 4221
• mRNA Refseq: NM_130799.3
• Protein Refseq: NP_570711.2
• MIM: 613733
• UniProt ID: O00255