Recombinant Full Length Human MKNK1 Protein, C-Flag-tagged

• Cat.No.: MKNK1-682HFL
• Product Overview: Recombinant Full Length Human MKNK1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 51.2 kDa
• AA Sequence: MVSSQKLEKPIEMGSSEPLPIADGD RRRKKKRRGRATDSLPGKFEDMYKL TSELLGEGAYAKVQGAVSLQ NGKEYAVKIIEKQAGHSRSRVFREV ETLYQCQGNKNILELIEFFEDDTRF YLVFEKLQGGSILAHIQKQK HFNEREASRVVRDVAAALDFLHTKD KVSLCHLGWSAMAPSGLTAAPTSLG SSDPPTSASQVAGTTGIAHR DLKPENILCESPEKVSPVKICDFDL GSGMKLNNSCTPITTPELTTPCGSA EYMAPEVVEVFTDQATFYDK RCDLWSLGVVLYIMLSGYPPFVGHC GADCGWDRGEVCRVCQNKLFESIQE GKYEFPDKDWAHISSEAKDL ISKLLVRDAKQRLSAAQVLQHPWVQ GQAPEKGLPTPQVLQRNSSTMDLTL FAAEAIALNRQLSQHEENEL
  AEEPEALADGLCSMKLSPPCKSRLA RRRALAQAGRGEDRSPPTALTRTRP LEQKLISEEDLAANDILDYKDDDDK V
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Insulin signaling pathway, MAPK signaling pathway

Gene Information

• Gene Name: MKNK1 MAPK interacting serine/threonine kinase 1 [ Homo sapiens (human) ]
• Official Symbol: MKNK1
• Synonyms: MNK1
• Gene ID: 8569
• mRNA Refseq: NM_003684.7
• Protein Refseq: NP_003675.3
• MIM: 606724
• UniProt ID: Q9BUB5