Recombinant Full Length Human MPEG1 Protein, C-Flag-tagged

• Cat.No.: MPEG1-1939HFL
• Product Overview: Recombinant Full Length Human MPEG1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 78.4 kDa
• AA Sequence: MNNFRATILFWAAAAWAKSGKPSGE MDEVGVQKCKNALKLPVLEVLPGGG WDNLRNVDMGRVMELTYSNC RTTEDGQYIIPDEIFTIPQKQSNLE MNSEILESWANYQSSTSYSINTELS LFSKVNGKFSTEFQRMKTLQ VKDQAITTRVQVRNLVYTVKINPTL ELSSGFRKELLDISDRLENNQTRMA TYLAELLVLNYGTHVTTSVD AGAALIQEDHLRASFLQDSQSSRSA VTASAGLAFQNTVNFKFEENYTSQN VLTKSYLSNRTNSRVQSIGG VPFYPGITLQAWQQGITNHLVAIDR SGLPLHFFINPNMLPDLPGPLVKKV SKTVETAVKRYYTFNTYPGC TDLNSPNFNFQANTDDGSCEGKMTN FSFGGVYQECTQLSGNRDVLLCQKL EQKNPLTGDFSCPSGYSPVH LLSQIHEEGYNHLECHRKCTLLVFC KTVCEDVFQVAKAEFRAFWCVASSQ VPENSGLLFGGLFSSKSINP MTNAQSCPAGYFPLRLFENLKVCVS QDYELGSRFAVPFGGFFSCTVGNPL VDPAISRDLGALSLKKCPGG FSQHPALISDGCQVSYCVKSGLFTG GSLPPARLPPFTRPPLMSQAATNTV IVTNSENARSWIKDSQTHQW RLGEPIELRRAMNVIHGDGGGLSGG AAAGVTVGVTTILAVVITLAIYGTR KFKKKAYQAIEERQSLVPGT AATGDTTYQEQGQSPA TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Transmembrane

Gene Information

• Gene Name: MPEG1 macrophage expressed 1 [ Homo sapiens (human) ]
• Official Symbol: MPEG1
• Synonyms: P-2; MPG1; MPS1; IMD77; Mpg-1
• Gene ID: 219972
• mRNA Refseq: NM_001039396.2
• Protein Refseq: NP_001034485.1
• MIM: 610390
• UniProt ID: Q2M385