Recombinant Full Length Human MYOC Protein, C-Flag-tagged

• Cat.No.: MYOC-296HFL
• Product Overview: Recombinant Full Length Human MYOC Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 56.8 kDa
• AA Sequence: MRFFCARCCSFGPEMPAVQLLLLAC LVWDVGARTAQLRKANDQSGRCQYT FSVASPNESSCPEQSQAMSV IHNLQRDSSTQRLDLEATKARLSSL ESLLHQLTLDQAARPQETQEGLQRE LGTLRRERDQLETQTRELET AYSNLLRDKSVLEEEKKRLRQENEN LARRLESSSQEVARLRRGQCPQTRD TARAVPPGSREVSTWNLDTL AFQELKSELTEVPASRILKESPSGY LRSGEGDTGCGELVWVGEPLTLRTA ETITGKYGVWMRDPKPTYPY TQETTWRIDTVGTDVRQVFEYDLIS QFMQGYPSKVHILPRPLESTGAVVY SGSLYFQGAESRTVIRYELN TETVKAEKEIPGAGYHGQFPYSWGG YTDIDLAVDEAGLWVIYSTDEAKGA IVLSKLNPENLELEQTWETN IRKQSVANAFIICGTLYTVSSYTSA DATVNFAYDTGTGISKTLTIPFKNR YKYSSMIDYNPLEKKLFAWD
  NLNMVTYDIKLSKMTRTRPLEQKLI SEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Secreted Protein

Gene Information

• Gene Name: MYOC myocilin [ Homo sapiens (human) ]
• Official Symbol: MYOC
• Synonyms: GPOA; JOAG; TIGR; GLC1A; JOAG1
• Gene ID: 4653
• mRNA Refseq: NM_000261.2
• Protein Refseq: NP_000252.1
• MIM: 601652
• UniProt ID: Q99972