Recombinant Full Length Human NRXN1 Protein, C-Flag-tagged

• Cat.No.: NRXN1-1316HFL
• Product Overview: Recombinant Full Length Human NRXN1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 158.8 kDa
• AA Sequence: MGTALLQRGGCFLLCLSLLLLGCWA ELGSGLEFPGAEGQWTRFPKWNACC ESEMSFQLKTRSARGLVLYF DDEGFCDFLELILTRGGRLQLSFSI FCAEPATLLADTPVNDGAWHSVRIR RQFRNTTLFIDQVEAKWVEV KSKRRDMTVFSGLFVGGLPPELRAA ALKLTLASVREREPFKGWIRDVRVN SSQVLPVDSGEVKLDDEPPN SGGGSPCEAGEEGEGGVCLNGGVCS VVDDQAVCDCSRTGFRGKDCSQEDN NVEGLAHLMMGDQGKSKGKE EYIATFKGSEYFCYDLSQNPIQSSS DEITLSFKTLQRNGLMLHTGKSADY VNLALKNGAVSLVINLGSGA FEALVEPVNGKFNDNAWHDVKVTRN LRQHSGIGHAMVTISVDGILTTTGY TQEDYTMLGSDDFFYVGGSP STADLPGSPVSNNFMGCLKEVVYKN NDVRLELSRLAKQGDPKMKIHGVVA FKCENVATLDPITFETPESF ISLPKWNAKKTGSISFDFRTTEPNG LILFSHGKPRHQKDAKHPQMIKVDF FAIEMLDGHLYLLLDMGSGT IKIKALLKKVNDGEWYHVDFQRDGR SGTISVNTLRTPYTAPGESEILDLD DELYLGGLPENKAGLVFPTE VWTALLNYGYVGCIRDLFIDGQSKD IRQMAEVQSTAGVKPSCSKETAKPC LSNPCKNNGMCRDGWNRYVC DCSGTGYLGRSCEREATVLSYDGSM FMKIQLPVVMHTEAEDVSLRFRSQR AYGILMATTSRDSADTLRLE LDAGRVKLTVNLDCIRINCNSSKGP ETLFAGYNLNDNEWHTVRVVRRGKS LKLTVDDQQAMTGQMAGDHT RLEFHNIETGIITERRYLSSVPSNF IGHLQSLTFNGMAYIDLCKNGDIDY CELNARFGFRNIIADPVTFK TKSSYVALATLQAYTSMHLFFQFKT TSLDGLILYNSGDGNDFIVVELVKG YLHYVFDLGNGANLIKGSSN KPLNDNQWHNVMISRDTSNLHTVKI DTKITTQITAGARNLDLKSDLYIGG VAKETYKSLPKLVHAKEGFQ GCLASVDLNGRLPDLISDALFCNGQ IERGCEGPSTTCQEDSCSNQGVCLQ QWDGFSCDCSMTSFSGPLCN DPGTTYIFSKGGGQITYKWPPNDRP STRADRLAIGFSTVQKEAVLVRVDS SSGLGDYLELHIHQGKIGVK FNVGTDDIAIEESNAIINDGKYHVV RFTRSGGNATLQVDSWPVIERYPAG RQLTIFNSQATIIIGGKEQG QPFQGQLSGLYYNGLKVLNMAAEND ANIAIVGNVRLVGEVPSSMTTESTA TAMQSEMSTSIMETTTTLAT STARRGKPPTKEPISQTTDDILVAS AECPSDDEDIDPCEPSSGGLANPTR AGGREPYPGSAEVIRESSST TGMVVGIVAAAALCILILLYAMYKY RNRDEGSYHVDESRNYISNSAQSNG AVVKEKQPSSAKSSNKNKKN
  KDKEYYVTRTRPLEQKLISEEDLAA NDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)

Gene Information

• Gene Name: NRXN1 neurexin 1 [ Homo sapiens (human) ]
• Official Symbol: NRXN1
• Synonyms: PTHSL2; SCZD17; Hs.22998
• Gene ID: 9378
• mRNA Refseq: NM_004801.6
• Protein Refseq: NP_004792.1
• MIM: 600565
• UniProt ID: Q9ULB1