Recombinant Full Length Human OPTN Protein, C-Flag-tagged

• Cat.No.: OPTN-765HFL
• Product Overview: Recombinant Full Length Human OPTN Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 65.7 kDa
• AA Sequence: MSHQPLSCLTEKEDSPSESTGNGPP HLAHPNLDTFTPEELLQQMKELLTE NHQLKEAMKLNNQAMKGRFE ELSAWTEKQKEERQFFEIQSKEAKE RLMALSHENEKLKEELGKLKGKSER SSEDPTDDSRLPRAEAEQEK DQLRTQVVRLQAEKADLLGIVSELQ LKLNSSGSSEDSFVEIRMAEGEAEG SVKEIKHSPGPTRTVSTGTA LSKYRSRSADGAKNYFEHEELTVSQ LLLCLREGNQKVERLEVALKEAKER VSDFEKKTSNRSEIETQTEG STEKENDEEKGPETVGSEVEALNLQ VTSLFKELQEAHTKLSEAELMKKRL QEKCQALERKNSAIPSELNE KQELVYTNKKLELQVESMLSEIKME QAKTEDEKSKLTVLQMTHNKLLQEH NNALKTIEELTRKESEKVDR AVLKELSEKLELAEKALASKQLQMD EMKQTIAKQEEDLETMTILRAQMEV YCSDFHAERAAREKIHEEKE QLALQLAVLLKENDAFEDGGRQSLM EMQSRHGARTSDSDQQAYLVQRGAE DRDWRQQRNIPIHSCPKCGE
  VLPDIDTLQIHVMDCIITRTRPLEQ KLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: OPTN optineurin [ Homo sapiens (human) ]
• Official Symbol: OPTN
• Synonyms: NRP; FIP2; HIP7; HYPL; ALS12; GLC1E; TFIIIA-INTP
• Gene ID: 10133
• mRNA Refseq: NM_001008211.1
• Protein Refseq: NP_001008212.1
• MIM: 602432
• UniProt ID: Q96CV9