Recombinant Full Length Human PYGL Protein

• Cat.No.: PYGL-416HF
• Product Overview: Recombinant full length Human PYGL with N terminal proprietary tag. Predicted MW 119.24 kDa.

Specification

• Species: Human
• Source: In Vitro Cell Free System
• Protein Length: 847 amino acids
• Description: This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Form: Liquid
• Molecular Mass: 119.240kDa inclusive of tags
• AA Sequence: MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTL VKDRNVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCP KRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGI RYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLP VHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVL YPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGST RGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRH LEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRI NMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLT KLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINP SSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSK LKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNM KFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFK DIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNT MVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE SNKVNGN
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione.

Gene Information

• Gene Name: PYGL phosphorylase, glycogen, liver [ Homo sapiens ]
• Official Symbol: PYGL
• Synonyms: PYGL; phosphorylase, glycogen, liver; phosphorylase, glycogen; liver; glycogen phosphorylase, liver form; glycogen storage disease type VI; Hers disease
• Gene ID: 5836
• mRNA Refseq: NM_001163940
• Protein Refseq: NP_001157412
• MIM: 613741
• UniProt ID: P06737