Recombinant Full Length Human RBBP7 Protein, C-Flag-tagged

• Cat.No.: RBBP7-1890HFL
• Product Overview: Recombinant Full Length Human RBBP7 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 47.6 kDa
• AA Sequence: MASKEMFEDTVEERVINEEYKIWKK NTPFLYDLVMTHALQWPSLTVQWLP EVTKPEGKDYALHWLVLGTH TSDEQNHLVVARVHIPNDDAQFDAS HCDSDKGEFGGFGSVTGKIECEIKI NHEGEVNRARYMPQNPHIIA TKTPSSDVLVFDYTKHPAKPDPSGE CNPDLRLRGHQKEGYGLSWNSNLSG HLLSASDDHTVCLWDINAGP KEGKIVDAKAIFTGHSAVVEDVAWH LLHESLFGSVADDQKLMIWDTRSNT TSKPSHLVDAHTAEVNCLSF NPYSEFILATGSADKTVALWDLRNL KLKLHTFESHKDEIFQVHWSPHNET ILASSGTDRRLNVWDLSKIG EEQSAEDAEDGPPELLFIHGGHTAK ISDFSWNPNEPWVICSVSEDNIMQI WQMAENIYNDEESDVTTSEL EGQGS TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: RBBP7 RB binding protein 7, chromatin remodeling factor [ Homo sapiens (human) ]
• Official Symbol: RBBP7
• Synonyms: RbAp46
• Gene ID: 5931
• mRNA Refseq: NM_002893.4
• Protein Refseq: NP_002884.1
• MIM: 300825
• UniProt ID: Q16576