Recombinant Full Length Human RXRG Protein, C-Flag-tagged

• Cat.No.: RXRG-2145HFL
• Product Overview: Recombinant Full Length Human RXRG Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 50.7 kDa
• AA Sequence: MYGNYSHFMKFPAGYGGSPGHTGST SMSPSAALSTGKPMDSHPSYTDTPV SAPRTLSAVGTPLNALGSPY RVITSAMGPPSGALAAPPGINLVAP PSSQLNVVNSVSSSEDIKPLPGLPG IGNMNYPSTSPGSLVKHICA ICGDRSSGKHYGVYSCEGCKGFFKR TIRKDLIYTCRDNKDCLIDKRQRNR CQYCRYQKCLVMGMKREAVQ EERQRSRERAESEAECATSGHEDMP VERILEAELAVEPKTESYGDMNMEN STNDPVTNICHAADKQLFTL VEWAKRIPHFSDLTLEDQVILLRAG WNELLIASFSHRSVSVQDGILLATG LHVHRSSAHSAGVGSIFDRV LTELVSKMKDMQMDKSELGCLRAIV LFNPDAKGLSNPSEVETLREKVYAT LEAYTKQKYPEQPGRFAKLL LRLPALRSIGLKCLEHLFFFKLIGD TPIDTFLMEMLETPLQIT TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Adipocytokine signaling pathway, Non-small cell lung cancer, Pathways in cancer, PPAR signaling pathway, Small cell lung cancer, Thyroid cancer

Gene Information

• Gene Name: RXRG retinoid X receptor gamma [ Homo sapiens (human) ]
• Official Symbol: RXRG
• Synonyms: RXRC; NR2B3; RXRgamma; RXR-gamma
• Gene ID: 6258
• mRNA Refseq: NM_006917.5
• Protein Refseq: NP_008848.1
• MIM: 180247
• UniProt ID: P48443