Description : |
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. |
Source : |
In Vitro Cell Free System |
Species : |
Human |
Tag : |
GST |
Form : |
50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Molecular Mass : |
85.9 kDa |
Protein Length : |
545 amino acids |
AA Sequence : |
MAEPSGSPVHVQLPQQAAPVTAAAA AAPAAATAAPAPAAPAAPAPAPAPA AQAVGWPICRDAYELQEVIGSGATA VVQAALCKPRQERVAIKRINLEKCQ TSMDELLKEIQAMSQCSHPNVVTYY TSFVVKDELWLVMKLLSGGSMLDII KYIVNRGEHKNGVLEEAIIATILKE VLEGLDYLHRNGQIHRDLKAGNILL GEDGSVQIADFGVSAFLATGGDVTR NKVRKTFVGTPCWMAPEVMEQVRGY DFKADMWSFGITAIELATGAAPYHK YPPMKVLMLTLQNDPPTLETGVEDK EMMKKYGKSFRKLLSLCLQKDPSKR PTAAELLKCKFFQKAKNREYLIEKL LTRTPDIAQRAKKVRRVPGSSGHLH KTEDGDWEWSDDEMDEKSEEGKAAF SQEKSRRVKEENPEIAVSASTIPEQ IQSLSVHDSQGPPNANEDYREASSC AVNLVLRLRNSRKELNDIRFEFTPG RDTADGVSQELFSAGLVDGHDVVIV AANLQKIVDDPKALKTLTFKLASGC DGSEIPDEVKLIGFAQLSVS |
Applications : |
Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : |
Best use within three months from the date of receipt of this protein |
Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |