Recombinant Full Length Human TTBK1 Protein, C-Flag-tagged

• Cat.No.: TTBK1-810HFL
• Product Overview: Recombinant Full Length Human TTBK1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene belongs to the casein kinase 1 superfamily. The encoded protein is a neuron-specific, serine/threonine and tyrosine kinase, which regulates phosphorylation of tau, a protein that associates with microtubule assemblies and stabilizes them. Genetic variants in this gene are associated with Alzheimer's disease.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 142.6 kDa
• AA Sequence: MQCLAAALKDETNMSGGGEQADILP ANYVVKDRWKVLKKIGGGGFGEIYE AMDLLTRENVALKVESAQQP KQVLKMEVAVLKKLQGKDHVCRFIG CGRNEKFNYVVMQLQGRNLADLRRS QPRGTFTLSTTLRLGKQILE SIEAIHSVGFLHRDIKPSNFAMGRL PSTYRKCYMLDFGLARQYTNTTGDV RPPRNVAGFRGTVRYASVNA HKNREMGRHDDLWSLFYMLVEFAVG QLPWRKIKDKEQVGMIKEKYEHRML LKHMPSEFHLFLDHIASLDY FTKPDYQLIMSVFENSMKERGIAEN EAFDWEKAGTDALLSTSTSTPPQQN TRQTAAMFGVVNVTPVPGDL LRENTEDVLQGEHLSDQENAPPILP GRPSEGLGPSPHLVPHPGGPEAEVW EETDVNRNKLRINIGKSPCV EEEQSRGMGVPSSPVRAPPDSPTTP VRSLRYRRVNSPESERLSTADGRVE LPERRSRMDLPGSPSRQACS SQPAQMLSVDTGHADRQASGRMDVS ASVEQEALSNAFRSVPLAEEEDFDS KEWVIIDKETELKDFPPGAE PSTSGTTDEEPEELRPLPEEGEERR RLGAEPTVRPRGRSMQALAEEDLQH LPPQPLPPQLSQGDGRSETS QPPTPGSPSHSPLHSGPRPRRRESD PTGPQRQVFSVAPPFEVNGLPRAVP LSLPYQDFKRDLSDYRERAR LLNRVRRVGFSHMLLTTPQVPLAPV QPQANGKEEEEEEEEDEEEEEEDEE EEEEEEEEEEEEEEEEEEEE EAAAAVALGEVLGPRSGSSSEGSER STDRSQEGAPSTLLADDQKESRGRA SMADGDLEPEEGSKTLVLVS PGDMKKSPVTAELAPDPDLGTLAAL TPQHERPQPTGSQLDVSEPGTLSSV LKSEPKPPGPGAGLGAGTVT TGVGGVAVTSSPFTKVERTFVHIAE KTHLNVMSSGGQALRSEEFSAGGEL GLELASDGGAVEEGARAPLE NGLALSGLNGAEIEGSALSGAPRET PSEMATNSLPNGPALADGPAPVSPL EPSPEKVATISPRRHAMPGS RPRSRIPVLLSEEDTGSEPSGSLSA KERWSKRARPQQDLARLVMEKRQGR LLLRLASGASSSSSEEQRRA SETLSGTGSEEDTPASEPAAALPRK SGRAAATRSRIPRPIGLRMPMPVAA QQPASRSHGAAPALDTAITS RLQLQTPPGSATAADLRPKQPPGRG LGPGRAQAGARPPAPRSPRLPASTS AARNASASPRSQSLSRRESP
  SPSHQARPGVPPPRGVPPARAQPDG TPSPGGSKKGPRGKLQAQRATTKGR AGGAEGRAGARTRTRPLEQKLISEE DLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase

Gene Information

• Gene Name: TTBK1 tau tubulin kinase 1 [ Homo sapiens (human) ]
• Official Symbol: TTBK1
• Synonyms: BDTK
• Gene ID: 84630
• mRNA Refseq: NM_032538.3
• Protein Refseq: NP_115927.1
• MIM: 619415
• UniProt ID: Q5TCY1