Recombinant Full Length Human XRCC6 Protein, C-Flag-tagged

• Cat.No.: XRCC6-484HFL
• Product Overview: Recombinant Full Length Human XRCC6 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 69.7 kDa
• AA Sequence: MSGWESYYKTEGDEEAEEEQEENLE ASGDYKYSGRDSLIFLVDASKAMFE SQSEDELTPFDMSIQCIQSV YISKIISSDRDLLAVVFYGTEKDKN SVNFKNIYVLQELDNPGAKRILELD QFKGQQGQKRFQDMMGHGSD YSLSEVLWVCANLFSDVQFKMSHKR IMLFTNEDNPHGNDSAKASRARTKA GDLRDTGIFLDLMHLKKPGG FDISLFYRDIISIAEDEDLRVHFEE SSKLEDLLRKVRAKETRKRALSRLK LKLNKDIVISVGIYNLVQKA LKPPPIKLYRETNEPVKTKTRTFNT STGGLLLPSDTKRSQIYGSRQIILE KEETEELKRFDDPGLMLMGF KPLVLLKKHHYLRPSLFVYPEESLV IGSSTLFSALLIKCLEKEVAALCRY TPRRNIPPYFVALVPQEEEL DDQKIQVTPPGFQLVFLPFADDKRK MPFTEKIMATPEQVGKMKAIVEKLR FTYRSDSFENPVLQQHFRNL EALALDLMEPEQAVDLTLPKVEAMN KRLGSLVDEFKELVYPPDYNPEGKV TKRKHDNEGSGSKRPKVEYS
  EEELKTHISKGTLGKFTVPMLKEAC RAYGLKSGLKKQELLEALTKHFQDT RTRPLEQKLISEEDLAANDILDYKD DDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Non-homologous end-joining

Gene Information

• Gene Name: XRCC6 X-ray repair cross complementing 6 [ Homo sapiens (human) ]
• Official Symbol: XRCC6
• Synonyms: ML8; KU70; TLAA; CTC75; CTCBF; G22P1
• Gene ID: 2547
• mRNA Refseq: NM_001469.5
• Protein Refseq: NP_001460.1
• MIM: 152690
• UniProt ID: P12956