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Recombinant HCV Nucleocapsid Protein, Biotin-labeled & beta-galactosidase conjugated

Cat.No. : Nucleocapsid-749H
Product Overview : The protein contains the HCV core nucleocapsid immunodominant regions, amino acids 2-192, with a molecular weight of 22 kDa and is biotin conjugated.The protein is fused to beta-galactosidase (114 kDa) at the N-terminus. Hepatitis C Virus core proteins are purified by proprietary chromatographic techniques.
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Description : The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum (ER) Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However, the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways In addition, HCV core antigen is a recently developed marker of hepatitis C infection. It is remarkably efficient at establishing persistent infection, suggesting that it has evolved one or more strategies aimed at evading the host immune response. T cell responses, including interferon-gamma production, are severely suppressed in chronic HCV patients. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR.
Source : E. coli
Species : Hepatitis C Virus
Form : 20 mM Tris-HCl pH 8.0 and 8 M urea
Molecular Mass : 136 kDa
Purity : > 95 % (SDS-PAGE)
Applications : ELISA; Western Blot
Storage : Store at -20 centigrade, avoid freeze/thaw cycles.
Official Symbol : Nucleocapsid
Synonyms : Nucleocapsid
Official Symbol : Nucleocapsid
Synonyms : Nucleocapsid

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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