Recombinant HIV-1 gp41 Antigen, Tag Free

• Cat.No.: gp41-08H
• Product Overview: Recombinant HIV-1 gp41 containing immunodominant epitopes from multiple HIV-1 clades (A, B, C, D, and E).

Specification

• Species: HIV
• Source: E.coli
• Tag: Non
• Description: The transmembrane protein gp41 (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
• Tag: Non
• Molecular Mass: 30 kDa
• Reactivity: Protein reacts with human HIV-1 antibody positive serum in Western Blot assay.
• Purity: ≥ 85% pure by SDS-PAGE
• Storage: At -60 centigrade or below
• Concentration: Approximately 0.3 mg/mL by absorbance at A280 nm
• Storage Buffer: Phosphate Buffered Saline (PBS), pH 7.4 and 0.3% N-Lauroylsarcosine

Gene Information

• Official Symbol: gp41
• Synonyms: env; Glycoprotein 41; gp41; TM; Transmembrane protein