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Recombinant Human ABCA2 protein, His-tagged

Cat.No. : ABCA2-13H
Product Overview : Recombinant Human ABCA2(Leu2201~Cys2436) fused with His tag at N-terminal was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Description : The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 30.4kDa
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 90%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others.
Gene Name : ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 [ Homo sapiens ]
Official Symbol : ABCA2
Synonyms : ABCA2; ATP-binding cassette, sub-family A (ABC1), member 2; ABC2; ATP-binding cassette sub-family A member 2; ATP-binding cassette 2; ATP-binding cassette transporter 2; ATP-binding cassette, sub-family A, member 2; MGC129761;
Gene ID : 20
mRNA Refseq : NM_001606
Protein Refseq : NP_001597
MIM : 600047
UniProt ID : Q9BZC7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Where is ABCA2 protein most expressed? 04/14/2023

ABCA2 is most highly expressed in the fetal and adult brain, spinal cord, ovaries and leukocytes.

What is the function of ABCA2? 04/14/2023

It may be a lipid transporter that modulates cholesterol sequestration in late endosomes/lysosomes. ABCA2 regulates the production of amyloid-beta by modulating the activation of signaling pathways that regulate the transcription of amyloid precursor proteins by regulating sphingolipid metabolism or by its role in the γ-secretase processing of APP. And it may play a role in myelin formation.

There is no recombinant ABCA2 protein in your catalog that meets my needs, is it possible to customize it? 04/14/2023

Sure, Creative BioMart supports custom protein production services.

What tag does your recombinant ABCA2 protein use? 04/14/2023

To improve the solubility and facilitate the subsequent experimental operation, our ABCA2 protein products use GST or His tags for your choice.

Which expression system does Creative BioMart's recombinant ABCA2 protein use? 04/14/2023

We offer a variety of expression systems, including E. coli, Yeast, Wheat Germ, and Mammalian Cell expression systems.

What species-derived recombinant ABCA2 proteins does your company offer? 04/14/2023

Creative BioMart offers recombinant ABCA2 proteins of several species, including human, mouse, and rat.

How to ensure that the recombinant protein reaches the customer safely and quickly? 04/14/2023

We will ensure the safety of the products on the road by putting them in ice bags or additional packaging outside the package according to the characteristics of the products.

Can I get a discount on the price? 04/14/2023

Discounts are available for first-time purchases and for holidays. For specific promotions, please contact our customer service staff. Thank you for your inquiry and we look forward to your order.

What is the tissue specificity of ABCA2 protein? 04/14/2023

ABCA2 is enriched in brain tissue and may play a role in neural development.

What is the full name of ABCA2? 04/14/2023

ATP binding cassette subfamily A member 2, and this protein is a member of the superfamily of ATP-binding cassette (ABC) transporters.

Customer Reviews (3)

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Reviews
09/15/2022

    I purchased the Abca2 recombinant protein and the quality is excellent, saving me weeks of research time.

    05/08/2021

      Customer service representatives have provided valuable assistance in helping to decide which products best meet our research needs.

      01/16/2020

        Creative BioMart's customer service is excellent, friendly and efficient, making it a worthwhile long-term partner.

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