Recombinant Human ABCD1, GST-tagged ABCD1-3738H

Recombinant Human ABCD1, GST-tagged

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Recombinant Human ABCD1, GST-tagged

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Cat.No. : ABCD1-3738H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human ABCD1(1 a.a. - 745 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ.
Description : The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.
Source : Wheat germ
Species : Human
Tag : GST
Molecular Mass : 109.3 kDa
AA Sequence : MPVLSRPRPW RGNTLKRTAV LLALAAYGAH KVYPLVRQCL APARGLQAPA GEPTQEASGV AAAKAGMNRV FLQRL LWLLRLLFPR VLCRETGLLA LHSAALVSRT FLSVYVARLD GRLARCIVRK DPRAFGWQLL QWLLIALPAT FVNSA IRYLEGQLAL SFRSRLVAHA YRLYFSQQTY YRVSNMDGRL RNPDQSLTED VVAFAASVAH LYSNLTKPLL DVAVT SYTLLRAARS RGAGTAWPSA IAGLVVFLTA NVLRAFSPKF GELVAEEARR KGELRYMHSR VVANSEEIAF YGGHE VELALLQRSY QDLASQINLI LLERLWYVML EQFLMKYVWS ASGLLMVAVP IITATGYSES DAEAVKKAAL EKKEE ELVSERTEAF TIARNLLTAA ADAIERIMSS YKEVTELAGY TARVHEMFQV FEDVQRCHFK RPRELEDAQA GSGTI GRSGVRVEGP LKIRGQVVDV EQGIICENIP IVTPSGEVVV ASLNIRVEEG MHLLITGPNG CGKSSLFRIL GGLWP TYGGVLYKPP PQRMFYIPQR PYMSVGSLRD QVIYPDSVED MQRKGYSEQD LEAILDVVHL HHILQREGGW EAMCD WKDVLSGGEK QRIGMARMFY HRPKYALLDE CTSAVSIDVE GKIFQAAKDA GIALLSITHR PSLWKYHTHL LQFDG EGGWKFEKLD SAARLSLTEE KQRLEQQLAG IPKMQRRLQE LCQILGEAVA PAHVPAPSPQ GPGGLQGAST
Applications : ELISA; WB-Re; AP; Array
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 [ Homo sapiens (human) ]
Official Symbol : ABCD1
Synonyms : ABCD1; ATP-binding cassette, sub-family D (ALD), member 1; ALD; ATP-binding cassette sub-family D member 1; adrenoleukodystrophy; ALDP; AMN; adrenoleukodystrophy protein; ABC42
Gene ID : 215
mRNA Refseq : NM_000033
Protein Refseq : NP_000024
MIM : 300371
UniProt ID : P33897
Chromosome Location : Xq28
Pathway : ABC transporters; Beta-oxidation of very long chain fatty acids; Peroxisomal lipid metabolism
Function : ATP binding; ATPase activity, coupled to transmembrane movement of substances; enzyme binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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